Malaria transmission and insecticide resistance of Anopheles gambiae in Libreville and Port-Gentil, Gabon

Malaria Journal

Research

Maryvonne Kombila¹  Jean-Romain Mourou¹  Fanny Jarjaval²  Thierry Coffinet²  Frédéric Pagès²  Rémi Amalvict³  Bruno Pradines³  Christophe Rogier³ 

[1] Département de Parasitologie-mycologie, Faculté de médecine, Université des Sciences de la Santé, B.P. 4009, Libreville, Gabon;UMR 6236, Unité d'entomologie médicale, IRBA antenne Marseille, Allée du Médecin Colonel Jamot, Parc du Pharo, BP 60109, 13262, Marseille Cedex 7, France;UMR 6236, Unité de parasitologie, IRBA antenne Marseille, Allée du Médecin colonel Jamot, parc du Pharo, BP 60109, 13262, Marseille Cedex 7, France;

关键词: Malaria;    Malaria Transmission;    Entomological Inoculation Rate;    Human Landing Catch;    Gambiae Complex;   

DOI  :  10.1186/1475-2875-9-321

 received in 2010-07-08, accepted in 2010-11-11,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundUrban malaria is a major health priority for civilian and militaries populations. A preliminary entomologic study has been conducted in 2006-2007, in the French military camps of the two mains towns of Gabon: Libreville and Port-Gentil. The aim was to assess the malaria transmission risk for troops.MethodsMosquitoes sampled by human landing collection were identified morphologically and by molecular methods. The Plasmodium falciparum circumsporozoïte (CSP) indexes were measured by ELISA, and the entomological inoculation rates (EIR) were calculated for both areas. Molecular assessments of pyrethroid knock down (kdr) resistance and of insensitive acetylcholinesterase resistance were conducted.ResultsIn Libreville, Anopheles gambiae s.s. S form was the only specie of the An. gambiae complex present and was responsible of 9.4 bites per person per night. The circumsporozoïte index was 0.15% and the entomological inoculation rate estimated to be 1.23 infective bites during the four months period. In Port-Gentil, Anopheles melas (75.5% of catches) and An. gambiae s.s. S form (24.5%) were responsible of 58.7 bites per person per night. The CSP indexes were of 1.67% for An. gambiae s.s and 0.28% for An. melas and the EIRs were respectively of 1.8 infective bites per week and of 0.8 infective bites per week. Both kdr-w and kdr-e mutations in An. gambiae S form were found in Libreville and in Port-Gentil. Insensitive acetylcholinesterase has been detected for the first time in Gabon in Libreville.ConclusionMalaria transmission exists in both town, but with high difference in the level of risk. The co-occurrence of molecular resistances to the main families of insecticide has implications for the effectiveness of the current vector control programmes that are based on pyrethroid-impregnated bed nets.

【 授权许可】

Unknown   
© Mourou et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.