Endoscopic nasobiliary drainage for obstructive jaundice using either a 5 Fr or 7 Fr catheter: a prospective, randomized trial

BMC Gastroenterology

Research Article

Shunsuke Watanabe¹  Kantaro Hisatomi¹  Koichi Kagawa¹  Nobuyuki Matsuhashi¹  Toshio Fujisawa¹  Hajime Sato²  Kensuke Kubota³  Atsushi Nakajima³ 

[1] Department of Gastroenterology, NTT Medical Centre Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa, 141-8625, Tokyo, Japan;Department of Health Policy and Technology Assessment, National Institute of Public Health, Saitama, Japan;Gastroenterology Division, Yokohama City University School of Medicine, Yokohama, Japan;

关键词: Nasobiliary catheter;    Obstructive jaundice;    Endoscopic biliary drainage;    Questionnaire survey;    Catheter size;   

DOI  :  10.1186/1471-230X-14-161

 received in 2014-07-10, accepted in 2014-09-12,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe influence of size on the effectiveness of nasobiliary catheters has not yet been studied. We compared biliary drainage effectiveness and procedure-related discomfort and adverse events in 5 French (Fr) and 7 Fr nasobiliary catheters.MethodsWe prospectively studied 100 patients undergoing endoscopic biliary drainage for obstructive jaundice, who were randomly allocated to a 5 Fr or 7 Fr nasobiliary catheter group. As the primary endpoint, the effectiveness was evaluated by the serum total bilirubin decreasing rate and the success rate of jaundice relief. As the secondary endpoint, the degree of discomfort was investigated using a questionnaire survey after catheter removal.ResultsThe bilirubin decrease rate was significantly higher in the 7 Fr catheter group than in the 5 Fr group (53.0 ± 21.4% vs 40.5 ± 29.9%, respectively; P = 0.019). The success rate of jaundice relief tended to be higher in the 7 Fr catheter group, although the difference was not statistically significant (98% vs 88%, respectively; P = 0.056). The questionnaire survey demonstrated that total discomfort was significantly greater in the 7 Fr group (3.9 ± 1.5 vs 3.2 ± 1.4, respectively; P = 0.018). Larger-diameter catheters tended to increase difficulty in eating, although the difference between the groups was not statistically significant.Conclusions7 Fr nasobiliary catheters are recommended for patients requiring rapid and reliable relief of obstructive jaundice. However, because they can cause greater discomfort, 5 Fr nasobiliary catheters are preferred in other settings.Trial registrationOn July 1, 2012; UMIN000008288 (Japan Primary Registries Network).

【 授权许可】

CC BY   
© Fujisawa et al.; licensee BioMed Central Ltd. 2014