期刊论文详细信息
Environmental Health
Identification of sources of lead exposure in French children by lead isotope analysis: a cross-sectional study
Research
Barbara Le Bot1  Philippe Glorennec2  Youssef Oulhote3  Denis Zmirou-Navier4  Anne Etchevers5  Joel Poupon6  Corinne Mandin7  Jean-Paul Lucas8 
[1] EHESP - School of Public Health, Sorbonne Paris Cité, 35043, Rennes, France;IRSET- Environmental and Occupational Health Research Institute, 35000, Rennes, France;EHESP - School of Public Health, Sorbonne Paris Cité, 35043, Rennes, France;IRSET- Environmental and Occupational Health Research Institute, 35000, Rennes, France;INSERM- French National Institute of Health and Medical Research, U625 (GERHM), Rennes 1 University, 35042, Rennes, France;EHESP - School of Public Health, Sorbonne Paris Cité, 35043, Rennes, France;IRSET- Environmental and Occupational Health Research Institute, 35000, Rennes, France;INSERM- French National Institute of Health and Medical Research, U954 Nancy University Medical School, 54505, Vandoeuvre Les Nancy, France;EHESP - School of Public Health, Sorbonne Paris Cité, 35043, Rennes, France;IRSET- Environmental and Occupational Health Research Institute, 35000, Rennes, France;INSERM- French National Institute of Health and Medical Research, U954 Nancy University Medical School, 54505, Vandoeuvre Les Nancy, France;Nancy University Medical School, 54505, Vandoeuvre Les Nancy, France;InVS - French Institute for Public Health Surveillance, 94415, Saint Maurice, France;Lariboisière Hospital (AP-HP), Toxicology laboratory, 75475, Paris, France;Paris Est University - CSTB - Scientific and Technical Building Centre, 77447, Marne-la-Vallée, France;Paris Est University - CSTB - Scientific and Technical Building Centre, 77447, Marne-la-Vallée, France;EA 4275 Biostatistics, Clinical Research and Subjective Measures in Health, Nantes University, 44035, Nantes, France;
关键词: Isotopic Signature;    Lead Concentration;    Lead Exposure;    Blood Lead Level;    Relative Standard Deviation;   
DOI  :  10.1186/1476-069X-10-75
 received in 2011-05-17, accepted in 2011-08-28,  发布年份 2011
来源: Springer
PDF
【 摘 要 】

BackgroundThe amount of lead in the environment has decreased significantly in recent years, and so did exposure. However, there is no known safe exposure level and, therefore, the exposure of children to lead, although low, remains a major public health issue. With the lower levels of exposure, it is becoming more difficult to identify lead sources and new approaches may be required for preventive action. This study assessed the usefulness of lead isotope ratios for identifying sources of lead using data from a nationwide sample of French children aged from six months to six years with blood lead levels ≥25 μg/L.MethodsBlood samples were taken from 125 children, representing about 600,000 French children; environmental samples were taken from their homes and personal information was collected. Lead isotope ratios were determined using quadrupole ICP-MS (inductively coupled plasma - mass spectrometry) and the isotopic signatures of potential sources of exposure were matched with those of blood in order to identify the most likely sources.ResultsIn addition to the interpretation of lead concentrations, lead isotope ratios were potentially of use for 57% of children aged from six months to six years with blood lead level ≥ 25 μg/L (7% of overall children in France, about 332,000 children), with at least one potential source of lead and sufficiently well discriminated lead isotope ratios. Lead isotope ratios revealed a single suspected source of exposure for 32% of the subjects and were able to eliminate at least one unlikely source of exposure for 30% of the children.ConclusionsIn France, lead isotope ratios could provide valuable additional information in about a third of routine environmental investigations.

【 授权许可】

CC BY   
© Oulhote et al; licensee BioMed Central Ltd. 2011

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