Evaluation of left ventricular ejection fraction using through-time radial GRAPPA

Journal of Cardiovascular Magnetic Resonance

Research

Nicole Seiberlich¹  Vidya Nadig²  Victoria Yeh³  Trevor Jenkins⁴  Abdus Sattar⁵  Prabhakar Rajiah⁶  Robert C Gilkeson⁶  Mark Griswold⁷  Vikas Gulani⁷  Gunhild Aandal⁸ 

[1] Biomedical Engineering, Case Western Reserve University, Room 309 Wickenden Building 2071 Martin Luther King Jr. Drive, 44106-7207, Cleveland, OH, USA;Cardiology, MetroHealth Medical Center at Case Western University, Cleveland, OH, USA;Case Western Reserve University School of Medicine, Cleveland, OH, USA;Division of Cardiovascular Medicine, Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA;Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA;Radiology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH, USA;Radiology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH, USA;Biomedical Engineering, Case Western Reserve University, Room 309 Wickenden Building 2071 Martin Luther King Jr. Drive, 44106-7207, Cleveland, OH, USA;Radiology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, OH, USA;Haraldsplass Deaconess Hospital, Bergen, Norway;

关键词: Real-time imaging;    Left ventricular ejection fraction;    Cardiovascular magnetic resonance;    Cardiac function;   

DOI  :  10.1186/s12968-014-0079-8

 received in 2014-03-03, accepted in 2014-09-01,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe determination of left ventricular ejection fraction using cardiovascular magnetic resonance (CMR) requires a steady cardiac rhythm for electrocardiogram (ECG) gating and multiple breathholds to minimize respiratory motion artifacts, which often leads to scan times of several minutes. The need for gating and breathholding can be eliminated by employing real-time CMR methods such as through-time radial GRAPPA. The aim of this study is to compare left ventricular cardiac functional parameters obtained using current gold-standard breathhold ECG-gated functional scans with non-gated free-breathing real-time imaging using radial GRAPPA, and to determine whether scan time or the occurrence of artifacts are reduced when using this real-time approach.Methods63 patients were scanned on a 1.5T CMR scanner using both the standard cardiac functional examination with gating and breathholding and the real-time method. Total scan durations were noted. Through-time radial GRAPPA was employed to reconstruct images from the highly accelerated real-time data. The blood volume in the left ventricle was assessed to determine the end systolic volume (ESV), end diastolic volume (EDV), and ejection fraction (EF) for both methods, and images were rated for the presence of artifacts and quality of specific image features by two cardiac readers. Linear regression analysis, Bland-Altman plots and two-sided t-tests were performed to compare the quantitative parameters. A two-sample t-test was performed to compare the scan durations, and a two-sample test of proportion was used to analyze the presence of artifacts. For the reviewers´ ratings the Wilcoxon test for the equality of the scores´ distributions was employed.ResultsThe differences in EF, EDV, and ESV between the gold-standard and real-time methods were not statistically significant (p-values of 0.77, 0.82, and 0.97, respectively). Additionally, the scan time was significantly shorter for the real-time data collection (p<0.001) and fewer artifacts were reported in the real-time images (p<0.01). In the qualitative image analysis, reviewers marginally preferred the standard images although some features including cardiac motion were equivalently rated.ConclusionReal-time functional CMR with through-time radial GRAPPA performed without ECG-gating under free-breathing can be considered as an alternative to gold-standard breathhold cine imaging for the evaluation of ejection fraction in patients.

【 授权许可】

Unknown   
© Aandal et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.