Transcriptomics profiling study of breast cancer from Kingdom of Saudi Arabia revealed altered expression of Adiponectin and Fatty Acid Binding Protein4: Is lipid metabolism associated with breast cancer?

BMC Genomics

Research

Abdelbaset Buhmeida¹  Ashraf Dallol¹  Hans-Juergen Schulten¹  Manikandan Jayapal¹  Mamdooh A GariI²  Sajjad Karim²  Mohammed H Al-Qahtani²  Adeel GA Chaudhary²  Adel M Abuzenadah³  Fatima Al-Thubaity⁴  Adnan Merdad⁴ 

[1] Center of Excellence in Genomic Medicine Research, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia;Center of Excellence in Genomic Medicine Research, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia;Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia;Center of Excellence in Genomic Medicine Research, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia;Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia;KACST Technology Innovation Center for Personalized Medicine at King Abdulaziz University, Jeddah, Saudi Arabia;Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia;

关键词: Breast cancer;    gene expression;    microarray;    lipid metabolism;    Saudi Arabia;   

DOI  :  10.1186/1471-2164-16-S1-S11

来源: Springer

【 摘 要 】

BackgroundBreast cancer incidence rates are increasing at an alarming rate among Saudi Arabian females. Most molecular genetic discoveries on breast cancer and other cancers have arisen from studies examining European and American patients. However, possibility of specific changes in molecular signature among cancer patients of diverse ethnic groups remains largely unexplored. We performed transcriptomic profiling of surgically-resected breast tumors from 45 patients based in the Western region of Saudi Arabia using Affymetrix Gene 1.0 ST chip. Pathway and biological function-based clustering was apparent across the tissue samples.ResultsPathway analysis revealed canonical pathways that had not been previously implicated in breast cancer. Biological network analysis of differentially regulated genes revealed that Fatty acid binding protein 4, adipocyte (FABP4), adiponectin (ADIPOQ), and retinol binding protein 4 (RBP4) were most down regulated genes, sharing strong connection with the other molecules of lipid metabolism pathway. The marked biological difference in the signatures uncovered between the USA and Saudi samples underpins the importance of this study. Connectivity Map identified compounds that could reverse an observed gene expression signatureConclusionsThis study describes, to our knowledge, the first genome-wide profiling of breast cancer from Saudi ethnic females. We demonstrate the involvement of the lipid metabolism pathway in the pathogenesis of breast cancer from this region. This finding also highlights the need for strategies to curb the increasing rates of incidence of this disease by educating the public about life-style risk factors such as unhealthy diet and obesity.

【 授权许可】

Unknown   
© MERDAD et al; licensee BioMed Central Ltd. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.