Protective effect of Zhuyeqing liquor, a Chinese traditional health liquor, on acute alcohol-induced liver injury in mice

Journal of Inflammation

Research

Guo-yu Li¹  Suo-ming Cheng¹  Hang-yu Wang¹  Jian Huang²  Hong-ying Gao²  Jin-hui Wang³  Li-fei Wang⁴  Xiao-wei Du⁴  Ying Han⁴ 

[1] School of Pharmacy, Shihezi University, 832002, Shihezi, P. R. China;School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Wenhua Road 103, 110016, Shenyang, P. R. China;School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Wenhua Road 103, 110016, Shenyang, P. R. China;School of Pharmacy, Shihezi University, 832002, Shihezi, P. R. China;Shanxi Xinghuacun Fen Jiu Group Co., Ltd, 450000, Shanxi, P. R. China;

关键词: Zhuyeqing liquor;    Hepatoprotective effect;    Alcohol;    Acute liver injury;   

DOI  :  10.1186/1476-9255-10-30

 received in 2013-04-18, accepted in 2013-09-26,  发布年份 2013

来源: Springer

【 摘 要 】

The study first evaluated the hepatoprotective effect of Zhuyeqing Liquor (ZYQL) against acute alcohol-induced liver injury in mice. Animals were administered orally with 50% alcohol 12 ml/kg at 4 h after the doses of ZYQL everyday for fourteen consecutive days except mice in normal group. The protective effect was evaluated by biochemical parameters including serum aspartate transaminase (AST), alanine transferase (ALT), total-bilirubin (TBIL) and reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD) in liver tissue. The result were confirmed histopathologically and the expression of TNF-α in mice liver was determined by immunohistochemistry analysis. HPLC-PDA was used for phytochemical analysis of ZYQL, and the plant source of each compound was claritied by UPLC-TOF-MS. The result showed that pretreatment with ZYQL exhibited a significant protective effect by reversing the biochemical parameters and histopathological changes in a dose depended manner. HPLC analysis indicated that ZYQL contained flavonoids, iridoids, terpenoids and phenolic acids, which might be the active chemicals. This study demonstrated the hepatoprotective activity of ZYQL, thus scientifically supported the function of its health care.

【 授权许可】

Unknown   
© Gao et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.