Exposure to anti-malarial drugs and monitoring of adverse drug reactions using toll-free mobile phone calls in private retail sector in Sagamu, Nigeria: implications for pharmacovigilance

Malaria Journal

Research

Omobola A Ogundahunsi¹  Olajide O Ayilara¹  Mufliat O Akinwunmi¹  Taofeeqah T Ademola¹  Isiaka A Ogunwande²  Ahmed A Adedeji³  Fatai A Fehintola⁴  Motunrayo Akinsanya⁵  Olubusola Ojo⁵  Bilqees Sanusi⁵  Azeez Tella⁵  Olubukola A Tikare⁶  Olumide AT Ogundahunsi⁷ 

[1] Communicable Disease Research Unit, Olabisi Onabanjo University Teaching Hospilal Sagamu, 2002, PMB, Nigeria;Communicable Disease Research Unit, Olabisi Onabanjo University Teaching Hospilal Sagamu, 2002, PMB, Nigeria;Department of Chemistry, Faculty of Science, Lagos State University, Ojo, Lagos, Nigeria;Communicable Disease Research Unit, Olabisi Onabanjo University Teaching Hospilal Sagamu, 2002, PMB, Nigeria;Department of Pharmacology, Olabisi Onabanjo University, 2022, Sagamu, PMB, Nigeria;Department of Pharmacology and Toxicology, Kampala International University- Western Campus, PO Box 71, Ishaka Bushenyi District, Uganda;Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria;Faculty of Pharmacy, Olabisi Onabanjo University, 2022, Sagamu, PMB, Nigeria;The School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX, London, UK;UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training on Tropical Diseases, Geneva, Switzerland;

关键词: Malaria;    Mobile Phone;    Community Pharmacy;    Artesunate;    Proguanil;   

DOI  :  10.1186/1475-2875-10-230

 received in 2011-04-21, accepted in 2011-08-09,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundAdverse drug reactions (ADRs) contribute to ill-health or life-threatening outcomes of therapy during management of infectious diseases. The exposure to anti-malarial and use of mobile phone technology to report ADRs following drug exposures were investigated in Sagamu - a peri-urban community in Southwest Nigeria.MethodsPurchase of medicines was actively monitored for 28 days in three Community Pharmacies (CP) and four Patent and Proprietary Medicine Stores (PPMS) in the community. Information on experience of ADRs was obtained by telephone from 100 volunteers who purchased anti-malarials during the 28-day period.Results and DiscussionA total of 12,093 purchases were recorded during the period. Antibiotics, analgesics, vitamins and anti-malarials were the most frequently purchased medicines. A total of 1,500 complete courses of anti-malarials were purchased (12.4% of total purchases); of this number, purchases of sulphadoxine-pyrimethamine (SP) and chloroquine (CQ) were highest (39.3 and 25.2% respectiuvely). Other anti-malarials purchased were artesunate monotherapy (AS) - 16.1%, artemether-lumefantrine (AL) 10.0%, amodiaquine (AQ) - 6.6%, quinine (QNN) - 1.9%, halofantrine (HF) - 0.2% and proguanil (PR) - 0.2%. CQ was the cheapest (USD 0.3) and halofantrine the most expensive (USD 7.7). AL was 15.6 times ($4.68) more expensive than CQ. The response to mobile phone monitoring of ADRs was 57% in the first 24 hours (day 1) after purchase and decreased to 33% by day 4. Participants in this monitoring exercise were mostly with low level of education (54%).ConclusionThe findings from this study indicate that ineffective anti-malaria medicines including monotherapies remain widely available and are frequently purchased in the study area. Cost may be a factor in the continued use of ineffective monotherapies. Availability of a toll-free telephone line may facilitate pharmacovigilance and follow up of response to medicines in a resource-poor setting.

【 授权许可】

CC BY   
© Adedeji et al; licensee BioMed Central Ltd. 2011