Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle

Cardiovascular Diabetology

Original Investigation

Christa Boer¹  Michaela Diamant²  Joanna WAM Bosmans³  Ronald Vlasblom³  Charissa E van den Brom³  Carla FM Molthoff⁴  Marc C Huisman⁴  Adriaan A Lammertsma⁴  Mark Lubberink⁴  Margriet D Ouwens⁵  Louis M Handoko⁶ 

[1] Department of Anaesthesiology, VU University Medical Centre, Amsterdam, the Netherlands;Department of Internal Medicine/Diabetes Centre, VU University Medical Centre, Amsterdam, the Netherlands;Department of Internal Medicine/Diabetes Centre, VU University Medical Centre, Amsterdam, the Netherlands;Laboratory for Physiology, VU University Medical Centre, Amsterdam, the Netherlands;Department of Nuclear Medicine & PET Research, VU University Medical Centre, Amsterdam, the Netherlands;German Diabetes Centre, Institute for Clinical Biochemistry and Pathobiochemistry, Düsseldorf, Germany;Laboratory for Physiology, VU University Medical Centre, Amsterdam, the Netherlands;Department of Pulmonology, VU University Medical Centre, Amsterdam, the Netherlands;

关键词: Left Ventricular;    Right Ventricular;    18FDG Positron Emission Tomography;    Diabetic Cardiomyopathy;    Right Ventricular Function;   

DOI  :  10.1186/1475-2840-9-25

 received in 2010-04-16, accepted in 2010-06-15,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundIn patients with myocardial infarction or heart failure, right ventricular (RV) dysfunction is associated with death, shock and arrhythmias. In patients with type 2 diabetes mellitus, structural and functional alterations of the left ventricle (LV) are highly prevalent, however, little is known about the impact of diabetes on RV characteristics. The purpose of the present study was to investigate whether LV changes are paralleled by RV alterations in a rat model of diabetes.MethodsZucker diabetic fatty (ZDF) and control (ZL) rats underwent echocardiography and positron emission tomography (PET) scanning using [18F]-2-fluoro-2-deoxy-D-glucose under hyperinsulinaemic euglycaemic clamp conditions. Glucose, insulin, triglycerides and fatty acids were assessed from trunk blood. Another group of rats received an insulin or saline injection to study RV insulin signaling.ResultsZDF rats developed hyperglycaemia, hyperinsulinaemia and dyslipidaemia (all p < 0.05). Echocardiography revealed depressed LV fractional shortening and tricuspid annular plane systolic excursion (TAPSE) in ZDF vs. ZL rats (both p < 0.05). A decrease in LV and RV insulin-mediated glucose utilisation was found in ZDF vs. ZL rats (both p < 0.05). LV associated with RV with respect to systolic function (r = 0.86, p < 0.05) and glucose utilisation (r = 0.74, p < 0.05). TAPSE associated with RV MRglu (r = 0.92, p < 0.05) and M-value (r = 0.91, p < 0.0001) and RV MRglu associated with M-value (r = 0.77, p < 0.05). Finally, reduced RV insulin-stimulated phosphorylation of Akt was found in ZDF vs. ZL (p < 0.05).ConclusionsLV changes were paralleled by RV alterations in insulin-stimulated glucose utilisation and RV systolic function in a rat model of diabetes, which may be attributed to ventricular interdependence as well as to the uniform effect of diabetes. Since diabetic patients are prone to develop diabetic cardiomyopathy and myocardial ischaemia, it might be suggested that RV dysfunction plays a central role in cardiac abnormalities in this population.

【 授权许可】

CC BY   
© van den Brom et al; licensee BioMed Central Ltd. 2010