Dysregulated expression of long noncoding RNAs in gynecologic cancers

Molecular Cancer

Review

Hamed Haddad Kashani¹  Hamed Sabzalipoor²  Elahe Seyed Hosseini³  Hossein Nikzad³  Matthieu Meryet-Figuiere⁴  Zatollah Asemi⁵ 

[1] Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran;Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran;Gametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran;Normandie Univ, UNICAEN, INSERM, ANTICIPE U1086 (Interdisciplinary Research for Cancers prevention and treatment, axis BioTICLA (Biology and Innovative Therapeutics for Ovarian Cancer), Caen, France;UNICANCER, Comprehensive Cancer Centre François Baclesse, Caen, France;Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan, Iran;

关键词: Long noncoding RNA;    Female reproductive system;    Ovarian cancer;    Endometrial cancer;    Cervical cancer;   

DOI  :  10.1186/s12943-017-0671-2

 received in 2017-03-06, accepted in 2017-05-26,  发布年份 2017

来源: Springer

【 摘 要 】

Cancers of the female reproductive system include ovarian, uterine, vaginal, cervical and vulvar cancers, which are termed gynecologic cancer. The emergence of long noncoding RNAs (lncRNAs), which are believed to play a crucial role in several different biological processes, has made the regulation of gene expression more complex. Although the function of lncRNAs is still rather elusive, their broad involvement in the initiation and progression of various cancers is clear. They are also involved in the pathogenesis of cancers of the female reproductive system. LncRNAs play a critical physiological role in apoptosis, metastasis, invasion, migration and cell proliferation in these cancers. Different expression profiles of lncRNAs have been observed in various types of tumors compared with normal tissues and between malignant and benign tumors. These differential expression patterns may lead to the promotion or suppression of cancer development and tumorigenesis. In the current review, we present the lncRNAs that show a differential expression between cancerous and normal tissues in ovarian, cervical and endometrial cancers, and highlight the associations between lncRNAs and some of the molecular pathways involved in these cancers.

【 授权许可】

CC BY   
© The Author(s). 2017