Traffic-related exposures and biomarkers of systemic inflammation, endothelial activation and oxidative stress: a panel study in the US trucking industry

Environmental Health

Research

Eric Garshick¹  Brent A Coull²  Andreas M Neophytou³  Thomas J Smith³  Douglas W Dockery³  Jaime E Hart⁴  Francine Laden⁴  Jennifer M Cavallari⁵ 

[1] Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;VA Boston Healthcare System, West Roxbury, MA, USA;Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA;Exposure Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Heath, Boston, MA, USA;Exposure Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Heath, Boston, MA, USA;Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;Exposure Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Heath, Boston, MA, USA;Division of Occupational and Environmental Medicine, University of Connecticut Health Center, Farmington, CT, USA;

关键词: Particulate matter;    Elemental carbon;    Organic carbon;    ICAM-1;    VCAM-1;    IL-6;    CRP;    Inflammation;    Endothelial activation;    Trucking industry;   

DOI  :  10.1186/1476-069X-12-105

 received in 2013-07-03, accepted in 2013-12-04,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundExperimental evidence suggests that inhaled particles from vehicle exhaust have systemic effects on inflammation, endothelial activation and oxidative stress. In the present study we assess the relationships of short-term exposures with inflammatory endothelial activation and oxidative stress biomarker levels in a population of trucking industry workers.MethodsBlood and urine samples were collected pre and post-shift, at the beginning and end of a workweek from 67 male non-smoking US trucking industry workers. Concurrent measurements of microenvironment concentrations of elemental and organic carbon (EC & OC), and fine particulate matter (PM2.5) combined with time activity patterns allowed for calculation of individual exposures. Associations between daily and first and last-day average levels of exposures and repeated measures of intercellular and vascular cell adhesion molecule-1 (ICAM-1 & VCAM-1), interleukin 6 (IL-6) and C-reactive protein (CRP) blood levels and urinary 8-Hydroxy-2′-Deoxyguanosine (8-OHdG) were assessed using linear mixed effects models for repeated measures.ResultsThere was a statistically significant association between first and last-day average PM2.5 and 8-OHdG (21% increase, 95% CI: 2, 42%) and first and last-day average OC and IL-6 levels (18% increase 95% CI: 1, 37%) per IQR in exposure. There were no significant findings associated with EC or associations suggesting acute cross-shift effects.ConclusionOur findings suggest associations between weekly average exposures of PM2.5 on markers of oxidative stress and OC on IL-6 levels.

【 授权许可】

CC BY   
© Neophytou et al.; licensee BioMed Central Ltd. 2013