The association between CYP1A1 genetic polymorphisms and coronary artery disease in the Uygur and Han of China

Lipids in Health and Disease

Research

Yi-Tong Ma¹  Yi-Ning Yang¹  Xiang Xie²  Dilare Adi²  Jin-Guo Zou²  Shuo Pan²  Bang-Dang Chen³  Fen Liu³ 

[1] Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, 830054, Urumqi, People’s Republic of China;Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, 830054, Urumqi, People’s Republic of China;Xinjiang Key Laboratory of Cardiovascular Disease Research, 830054, Urumqi, People’s Republic of China;Xinjiang Key Laboratory of Cardiovascular Disease Research, 830054, Urumqi, People’s Republic of China;

关键词: CYP1A1;    Single nucleotide polymorphism;    Coronary artery disease;    Case–control study;   

DOI  :  10.1186/1476-511X-13-145

 received in 2014-07-10, accepted in 2014-09-02,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) gene is expressed in the vascular endothelium, which metabolizes arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs). 20-HETE mediates cardiovascular homeostasis and growth response in vascular smooth muscle cells (VSMCs) as well as the anti-platelet effect. EETs are potent endogenous vasodilators and inhibitors of vascular inflammation. This study assessed the association between human CYP1A1 gene polymorphisms and coronary artery disease (CAD) in the Uygur and Han in China.MethodsTwo independent case–control studies that recruited Han (389 patients with CAD and 411 controls) and Uygur participants (293 patients with CAD and 408 controls) analyzed the relationship between CYP1A1 single nucleotide polymorphisms (SNPs: rs4886605, rs12441817, rs4646422 and rs1048943) and CAD. All patients with CAD and controls were genotyped for the four SNPs of CYP1A1 using TaqMan SNP genotyping assays.ResultsIn the Uygur group, the distribution of the dominant model(CC vs CT + TT) of rs4886605 for the total sample and the males was significantly different between CAD patients and control participants (P = 0.001 and P = 0.012, respectively), The difference remained significant after a multivariate adjustment (P = 0.018, P = 0.015, respectively). The rs12441817 was also associated with CAD in a dominant model for all participants (P = 0.003) and men (P = 0.012), and the difference remained significant after a multivariate adjustment (P = 0.016, P = 0.002, respectively). However, we did not observe differences in the Uygur females and Han group with regard to the allele frequency or genotypic distribution of rs4886605 and rs12441817 between patients with CAD and control participants. Patients with CAD did not significantly differ from the control participants with regard to the distributions of rs4646422 and rs1048943 genotypes, the dominant model, the recessive model, or allele frequency in the Han and Uygur groups.ConclusionBoth rs4886605 and rs12441817 SNPs of the CYP1A1 gene are associated with CAD in the Uygur population of China.

【 授权许可】

Unknown   
© Zou et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.