Extracranial propagation of glioblastoma with extension to pterygomaxillar fossa

World Journal of Surgical Oncology

Case Report

Damir Tomac¹  Darko Chudy¹  Gordan Grahovac¹  Iva Topić²  Smiljka Lambaša³  Arijana Zoric⁴ 

[1] Department of Neurosurgery, Clinical Hospital Dubrava, Zagreb, Croatia;Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Hospital Center Zagreb, Croatia;Department of Pathology, Clinical Hospital Dubrava, Zagreb, Croatia;Rudjer Boskovic Institute, Division for Molecular Medicine, Laboratory of Molecular Oncology, Zagreb, Croatia;

关键词: Nasal Cavity;    Temozolomide;    Skull Base;    Glioblastoma Multiforme;    Sphenoid Sinus;   

DOI  :  10.1186/1477-7819-9-53

 received in 2010-12-20, accepted in 2011-05-19,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundGlioblastoma multiforme is a highly malignant primary brain tumor that shows marked local aggressiveness, but extracranial spread is not a common occurrence. We present an unusual case of recurrent glioblastoma in 54-year old male that spread through the scull base to the ethmoid and sphenoid sinuses, to the orbita, pterygomaxillar fossa, and to the neck.MethodsA 54-year old male underwent left temporal resection because of brain tumor of his left temporal lobe. Operation was followed by external beam radiation combined with temozolomide. The tumor recurred eight months after first surgery. The patient developed swelling of left temporal region, difficult swallowing and headache. MRI of head showed recurrent tumor, which invaded orbita, ethmoid and sphenoid sinuses, nasal cavity, pterygomaxillar fossa.ResultsThe patient died ten months after initial diagnosis of glioblastoma multiforme, and two months after his second operation.ConclusionsThe aggressive surgical operation helped to downsize the tumor mass as much as possible, but did not prolonged significantly the life or improved the life quality of the patient. The current literature is reviewed, and the diagnostic approaches as well as therapeutic options are discussed.

【 授权许可】

Unknown   
© Tomac et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.