Age-related normal structural and functional ventricular values in cardiac function assessed by magnetic resonance

BMC Medical Imaging

Research Article

Costantina Manes¹  Barbara E Stähli¹  Felix C Tanner²  Tobias A Fuchs³  Catherine Gebhard³  Julia Stehli³  Bernd Klaeser³  Robert Manka⁴  Oliver Gaemperli⁴  Philipp A Kaufmann⁵  Michael Fiechter⁵ 

[1]Department of Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland

[2]Department of Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland

[3]Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland

[4]Department of Radiology, Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland

[5]Department of Radiology, Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland

[6]Department of Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland

[7]Department of Radiology, Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland

[8]Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland

关键词: CMR;    Age;    LV-EF;    RV-EF;    Normal values;   

DOI  :  10.1186/1471-2342-13-6

 received in 2012-10-16, accepted in 2013-01-25,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe heart is subject to structural and functional changes with advancing age. However, the magnitude of cardiac age-dependent transformation has not been conclusively elucidated.MethodsThis retrospective cardiac magnetic resonance (CMR) study included 183 subjects with normal structural and functional ventricular values. End systolic volume (ESV), end diastolic volume (EDV), and ejection fraction (EF) were obtained from the left and the right ventricle in breath-hold cine CMR. Patients were classified into four age groups (20–29, 30–49, 50–69, and ≥70 years) and cardiac measurements were compared using Pearson’s rank correlation over the four different groups.ResultsWith advanced age a slight but significant decrease in ESV (r=−0.41 for both ventricles, P<0.001) and EDV (r=−0.39 for left ventricle, r=−0.35 for right ventricle, P<0.001) were observed associated with a significant increase in left (r=0.28, P<0.001) and right (r=0.27, P<0.01) ventricular EF reaching a maximal increase in EF of +8.4% (P<0.001) for the left and +6.1% (P<0.01) for the right ventricle in the oldest compared to the youngest patient group. Left ventricular myocardial mass significantly decreased over the four different age groups (P<0.05).ConclusionsThe aging process is associated with significant changes in left and right ventricular EF, ESV and EDV in subjects with no cardiac functional and structural abnormalities. These findings underline the importance of using age adapted values as standard of reference when evaluating CMR studies.

【 授权许可】

Unknown   
© Fiechter et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.