The relationship between serum hypoxia-inducible factor 1α and coronary artery calcification in asymptomatic type 2 diabetic patients

Cardiovascular Diabetology

Original Investigation

Rong Ai¹  Fang Chen²  Zhong-zhi Tang³  Wei-hua Lu³  Jian-hong Yang³  Gang Li³ 

[1] College of Foreign Language, Huazhong Agriculture University, Hongshan, 430070, Wuhan, Hubei, China;Department of Medicine Laboratory, Wuhan General Hospital of Guangzhou Military Command, Wuhan, China;Emergency Department, Wuhan General Hospital of Guangzhou Military Command, Wu Luo Road, Hong Shan, Wuhan, China;

关键词: Hypoxia-inducible factor 1α;    Coronary artery calcification;    Atherosclerosis;    Type 2 diabetes mellitus;   

DOI  :  10.1186/1475-2840-13-52

 received in 2013-12-05, accepted in 2014-02-20,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundHypoxia-inducible factor 1 (HIF-1), a master regulator of oxygen homeostasis, is a heterodimer consisting of HIF-1α and HIF-1β subunits, and is implicated in calcification of cartilage and vasculature. The goal of this study was to determine the relationship between serum HIF-1α with coronary artery calcification (CAC) in patients with type 2 diabetes.MethodsThe subjects were 405 (262 males, 143 females, age 51.3 ± 6.4 years) asymptomatic patients with type 2 diabetes mellitus. Serum HIF-1α and interleukin-6 (IL-6) levels were measured by ELISA. CAC scores were assessed by a 320-slice CT scanner. The subjects were divided into 4 quartiles depending on serum HIF-1α levels.ResultsAverage serum HIF-1α was 184.4 ± 66.7 pg/ml. Among patients with higher CAC scores, HIF-1α levels were also significantly increased (p <0.001). HIF-1α levels positively correlated with CRP, IL-6, UKPDS risk score, HbA1c, FBG, and CACS, but did not correlate with diabetes duration, age, and LDL. According to the multivariate analysis, HIF-1α levels significantly and independently predict the presence of CAC. ROC curve analysis showed that the serum HIF-1α level can predict the extent of CAC, but the specificity was lower than the traditional risk factors UKPDS and HbA1c.ConclusionAs a marker of hypoxia, serum HIF-1α level may be an independent risk factor for the presence of CAC. These findings indicate that elevated serum HIF-1α may be involved in vascular calcification in patients with type 2 diabetes mellitus.

【 授权许可】

CC BY   
© Li et al.; licensee BioMed Central Ltd. 2014