Inter-study reproducibility of cardiovascular magnetic resonance tagging

Journal of Cardiovascular Magnetic Resonance

Research

Seth Berkowitz¹  Sirisha Donekal¹  Bharath Ambale-Venkatesh¹  Eui Young Choi¹  Raymond Yan¹  Veronica Fernandes¹  Joao A C Lima¹  David A Bluemke²  Colin O Wu³  Ahmed A Harouni⁴ 

[1] Department of Cardiology, Johns Hopkins University, 600 N Wolfe Street, 21287, Baltimore, MD, USA;Department of Cardiology, Johns Hopkins University, 600 N Wolfe Street, 21287, Baltimore, MD, USA;Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive, 20892-1074, Bethesda, MD, USA;Department of statistics, National Institutes of Health, Two Rockledge Center, 20892, Bethesda, MD, USA;Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive, 20892-1074, Bethesda, MD, USA;

关键词: CMR tagging;    HARP;    Test-retest reproducibility;    SPAMM;    Circumferential strain;    Radial strain;    Principal strains;    Torsion;   

DOI  :  10.1186/1532-429X-15-37

 received in 2012-05-31, accepted in 2013-04-29,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe aim of this study is to determine the test-retest reliability of the measurement of regional myocardial function by cardiovascular magnetic resonance (CMR) tagging using spatial modulation of magnetization.MethodsTwenty-five participants underwent CMR tagging twice over 12 ± 7 days. To assess the role of slice orientation on strain measurement, two healthy volunteers had a first exam, followed by image acquisition repeated with slices rotated ±15 degrees out of true short axis, followed by a second exam in the true short axis plane. To assess the role of slice location, two healthy volunteers had whole heart tagging. The harmonic phase (HARP) method was used to analyze the tagged images. Peak midwall circumferential strain (Ecc), radial strain (Err), Lambda 1, Lambda 2, and Angle α were determined in basal, mid and apical slices. LV torsion, systolic and early diastolic circumferential strain and torsion rates were also determined.ResultsLV Ecc and torsion had excellent intra-, interobserver, and inter-study intra-class correlation coefficients (ICC range, 0.7 to 0.9). Err, Lambda 1, Lambda 2 and angle had excellent intra- and interobserver ICC than inter-study ICC. Angle had least inter-study reproducibility. Torsion rates had superior intra-, interobserver, and inter-study reproducibility to strain rates. The measurements of LV Ecc were comparable in all three slices with different short axis orientations (standard deviation of mean Ecc was 0.09, 0.18 and 0.16 at basal, mid and apical slices, respectively). The mean difference in LV Ecc between slices was more pronounced in most of the basal slices compared to the rest of the heart.ConclusionsIntraobserver and interobserver reproducibility of all strain and torsion parameters was excellent. Inter-study reproducibility of CMR tagging by SPAMM varied between different parameters as described in the results above and was superior for Ecc and LV torsion. The variation in LV Ecc measurement due to altered slice orientation is negligible compared to the variation due to slice location.Trial registrationThis trial is registered as NCT00005487 at National Heart, Lung and Blood institute.

【 授权许可】

Unknown   
© Donekal et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.