Cardiovascular magnetic resonance compatible physical model of the left ventricle for multi-modality characterization of wall motion and hemodynamics

Journal of Cardiovascular Magnetic Resonance

Research

Ikechukwu U. Okafor¹  Ajit P. Yoganathan²  Arvind Santhanakrishnan³  Lucia Mirabella⁴  Brandon D. Chaffins⁴  John N. Oshinski⁵ 

[1] School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA;School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA;Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA;School of Mechanical & Aerospace Engineering, Oklahoma State University, Stillwater, OK, USA;Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA;Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA;Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, GA, USA;

关键词: Cardiovascular magnetic resonance;    Left ventricle phantom;    MR segmentation;    MR reconstruction;    MR validation;    Particle image velocimetry;    Stereo-photogrammetry;    FSI validation;   

DOI  :  10.1186/s12968-015-0154-9

 received in 2015-01-24, accepted in 2015-06-10,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe development of clinically applicable fluid-structure interaction (FSI) models of the left heart is inherently challenging when using in vivo cardiovascular magnetic resonance (CMR) data for validation, due to the lack of a well-controlled system where detailed measurements of the ventricular wall motion and flow field are available a priori. The purpose of this study was to (a) develop a clinically relevant, CMR-compatible left heart physical model; and (b) compare the left ventricular (LV) volume reconstructions and hemodynamic data obtained using CMR to laboratory-based experimental modalities.MethodsThe LV was constructed from optically clear flexible silicone rubber. The geometry was based off a healthy patient’s LV geometry during peak systole. The LV phantom was attached to a left heart simulator consisting of an aorta, atrium, and systemic resistance and compliance elements. Experiments were conducted for heart rate of 70 bpm. Wall motion measurements were obtained using high speed stereo-photogrammetry (SP) and cine-CMR, while flow field measurements were obtained using digital particle image velocimetry (DPIV) and phase-contrast magnetic resonance (PC-CMR).ResultsThe model reproduced physiologically accurate hemodynamics (aortic pressure = 120/80 mmHg; cardiac output = 3.5 L/min). DPIV and PC-CMR results of the center plane flow within the ventricle matched, both qualitatively and quantitatively, with flow from the atrium into the LV having a velocity of about 1.15 m/s for both modalities. The normalized LV volume through the cardiac cycle computed from CMR data matched closely to that from SP. The mean difference between CMR and SP was 5.5 ± 3.7 %.ConclusionsThe model presented here can thus be used for the purposes of: (a) acquiring CMR data for validation of FSI simulations, (b) determining accuracy of cine-CMR reconstruction methods, and (c) conducting investigations of the effects of altering anatomical variables on LV function under normal and disease conditions.

【 授权许可】

Unknown   
© Okafor et al. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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