Relationship between coronary flow reserve evaluated by phase-contrast cine cardiovascular magnetic resonance and serum eicosapentaenoic acid

Journal of Cardiovascular Magnetic Resonance

Research

Ikuyoshi Kusama¹  Shingo Kato¹  Masashi Koga¹  Tatsuya Nakachi¹  Takeshi Nakagawa¹  Kazuki Fukui¹  Yuka Kusakawa¹  Nao Ishii¹  Satoshi Umemura²  Kazuaki Uchino²  Yasuo Terauchi³  Junko Kawaguchi³  Kazuo Kimura⁴ 

[1] Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomiokahigashi, Kanazawa-ku, 236-0051, Yokohama, Kanagawa, Japan;Department of Cardiology, Yokohama City University Hospital, Yokohama, Japan;Department of Endocrinology and Metabolism, Yokohama City University Hospital, Yokohama, Japan;Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan;

关键词: Cardiovascular Magnetic Resonance;    Late Gadolinium Enhancement;    Coronary Sinus;    Coronary Flow Reserve;    Coronary Artery Disease Patient;   

DOI  :  10.1186/1532-429X-15-106

 received in 2013-07-17, accepted in 2013-12-11,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundLong-term intake of long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs), especially eicosapentaenoic acid (EPA) is associated with a low risk for cardiovascular disease. Phase-contrast cine cardiovascular magnetic resonance (PC cine CMR) can assess coronary flow reserve (CFR). The present study investigates the relationship between CFR evaluated by PC cine CMR and the serum EPA.MethodsWe studied 127 patients (male, 116 (91%); mean age, 72.2 ± 7.4 years) with known or suspected coronary artery disease (CAD). X-ray coronary angiography revealed no significant coronary arterial stenoses (defined as luminal diameter reduction ≥50% on quantitative coronary angiogram (QCA) analysis) in all study participants. Breath-hold PC cine CMR images of the coronary sinus (CS) were acquired to assess blood flow of the CS both at rest and during adenosine triphosphate (ATP) infusion. We calculated CFR as CS blood flow during ATP infusion divided by that at rest. Patients were allocated to groups according to whether they had high (n = 64, EPA ≥ 75.8 μg/mL) or low (n = 63, EPA < 75.8 μg/mL) median serum EPA.ResultsCFR was significantly lower in the low, than in the high EPA group (2.54 ± 1.00 vs. 2.91 ± 0.98, p = 0.038). Serum EPA positively correlated with CFR (R = 0.35, p < 0.001). We defined preserved CFR as > 2.5, which is the previously reported lower limit of normal flow reserve without obstructive CAD. Multivariate analysis revealed that EPA is an independent predictor of CFR > 2.5 (odds ratio, 1.01; 95% confidence interval, 1.00 – 1.02, p = 0.008).ConclusionsThe serum EPA is significantly correlated with CFR in CAD patients without significant coronary artery stenosis.

【 授权许可】

CC BY   
© Kato et al.; licensee BioMed Central Ltd. 2013