State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis

EJNMMI Radiopharmacy and Chemistry

Review

Danielle J. Vugts¹  Lizeth Y. F. Haveman²  Albert D. Windhorst³ 

[1] Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands;Cancer Center Amsterdam (CCA), Amsterdam, The Netherlands;Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands;Chemistry and Pharmaceutical Sciences, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Amsterdam, The Netherlands;Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands;Neuroscience Amsterdam, Amsterdam, The Netherlands;

关键词: Radiopharmaceutical chemistry;    Fluorine-18;   

DOI  :  10.1186/s41181-023-00203-5

 received in 2023-07-24, accepted in 2023-08-03,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPositron emission tomography (PET) is a powerful, non-invasive preclinical and clinical nuclear imaging technique used in disease diagnosis and therapy assessment. Fluorine-18 is the predominant radionuclide used for PET tracer synthesis. An impressive variety of new ‘late-stage’ radiolabeling methodologies for the preparation of 18F-labeled tracers has appeared in order to improve the efficiency of the labeling reaction.Main bodyDespite these developments, one outstanding challenge into the early key steps of the process remains: the preparation of reactive [18F]fluoride from oxygen-18 enriched water ([18O]H2O). In the last decade, significant changes into the trapping, elution and drying stages have been introduced. This review provides an overview of the strategies and recent developments in the production of reactive [18F]fluoride and its use for radiolabeling.ConclusionImproved, modified or even completely new fluorine-18 work-up procedures have been developed in the last decade with widespread use in base-sensitive nucleophilic 18F-fluorination reactions. The many promising developments may lead to a few standardized drying methodologies for the routine production of a broad scale of PET tracers.

【 授权许可】

CC BY   
© Springer Nature Switzerland AG 2023

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