Maternal occupational exposure and oral clefts in offspring

Environmental Health

Research

H. Marike Boezen¹  Nynke Spinder²  Jorieke E. H. Bergman³  Hermien E. K. de Walle³  Roel C. H. Vermeulen⁴  Hans Kromhout⁴ 

[1]Department of Epidemiology, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, HPC FA 40, 9700 RB, Groningen, the Netherlands

[2]Department of Epidemiology, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, HPC FA 40, 9700 RB, Groningen, the Netherlands

[3]Department of Genetics, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, HPC CB 51, 9700 RB, Groningen, the Netherlands

[4]Department of Genetics, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, HPC CB 51, 9700 RB, Groningen, the Netherlands

[5]Division of Environmental Epidemiology, Institute for Risk Assessment Science, Utrecht University, Postbox 80178, 3508 TD, Utrecht, the Netherlands

关键词: Biological dust;    Congenital anomalies;    Job-exposure matrix;    Metals;    Mineral dust;    Occupational exposure;    Pesticides;    Solvents;    Teratology;   

DOI  :  10.1186/s12940-017-0294-5

 received in 2016-10-13, accepted in 2017-08-01,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundPrevious studies suggest that periconceptional maternal occupational exposure to solvents and pesticides increase the risk of oral clefts in the offspring. Less is known about the effect of occupational exposure to metals, dust, and gases and fumes on development of oral clefts.MethodsThis case-malformed control study used data from a population-based birth defects registry (Eurocat) of children and foetuses born in the Northern Netherlands between 1997 and 2013. Cases were defined as non-syndromic oral clefts. The first control group had chromosomal/monogenic defects, and the second control group was defined as non-chromosomal/non-monogenic malformed controls. Maternal occupational exposure was estimated through linkage of mothers’ occupation with a community-based Job Exposure Matrix (JEM). Multivariate logistic regression was used to estimate the effect of occupational exposures. Odds ratios were adjusted (aORs) for relevant confounders.ResultsA total of 387 cases, 1135 chromosomal and 4352 non-chromosomal malformed controls were included in this study. Prevalence of maternal occupational exposures to all agents was 43.9% and 41.0%/37.7% among cases and controls, respectively. Oral clefts had significantly increased ORs of maternal occupational exposure to pesticides (aOR = 1.7, 95% confidence interval [CI] 1.0–3.1) and dust (aOR = 1.3, 95% CI 1.1–1.6) when using non-chromosomal controls. Subgroup analysis for CL(P) stratified by gender showed a significantly increased risk for male infants exposed to ‘other solvents’ and exposure to mineral dust for female infants.ConclusionOur study showed that maternal occupational exposure to pesticides and dust are risk factors for oral clefts in the offspring. Larger studies are needed to confirm this finding.

【 授权许可】

CC BY   
© The Author(s). 2017