Risk of hematological malignancies associated with magnetic fields exposure from power lines: a case-control study in two municipalities of northern Italy

Environmental Health

Research

Barbara Notari¹  Maurizio Bruni¹  Elena Ballotti²  Maurizio Poli²  Marco Vinceti³  Carlotta Malagoli³  Paolo Paolucci⁴  Giovanni Palazzi⁴  Sara Fabbi⁵  Sergio Teggi⁵  Mariagiulia Calzari⁶ 

[1] ARPA - Emilia Romagna Environmental Protection Agency, section of Modena, via Fontanelli 23, 41121, Modena, Italy;ARPA - Emilia Romagna Environmental Protection Agency, section of Reggio Emilia, via Amendola 2, 42122, Reggio Emilia, Italy;CREAGEN - Environmental, Genetic and Nutritional Epidemiology Research Center, Department of Public Health Sciences, University of Modena and Reggio Emilia, via Campi 287, 41125, Modena, Italy;Department of Mother and Child, University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy;LARMA - Laboratory of Environmental Analysis, Surveying and Environmental Monitoring, Department of Mechanical and Civil Engineering, University of Modena and Reggio Emilia, via Vignolese 905, 41125, Modena, Italy;Local Health Unit of Reggio Emilia, via Amendola 2, 42122, Reggio Emilia, Italy;

关键词: Acute Lymphoblastic Leukemia;    Power Line;    Magnetic Field Intensity;    Childhood Leukemia;    Hematological Cancer;   

DOI  :  10.1186/1476-069X-9-16

 received in 2009-12-16, accepted in 2010-03-30,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundSome epidemiologic studies have suggested an association between electromagnetic field exposure induced by high voltage power lines and childhood leukemia, but null results have also been yielded and the possibility of bias due to unmeasured confounders has been suggested.MethodsWe studied this relation in the Modena and Reggio Emilia municipalities of northern Italy, identifying the corridors along high voltage power lines with calculated magnetic field intensity in the 0.1-<0.2, 0.2-<0.4, and ≥ 0.4 microTesla ranges. We identified 64 cases of newly-diagnosed hematological malignancies in children aged <14 within these municipalities from 1986 to 2007, and we sampled four matched controls for each case, collecting information on historical residence and parental socioeconomic status of these subjects.ResultsRelative risk of leukemia associated with antecedent residence in the area with exposure ≥ 0.1 microTesla was 3.2 (6.7 adjusting for socioeconomic status), but this estimate was statistically very unstable, its 95% confidence interval being 0.4-23.4, and no indication of a dose-response relation emerged. Relative risk for acute lymphoblastic leukemia was 5.3 (95% confidence interval 0.7-43.5), while there was no increased risk for the other hematological malignancies.ConclusionsThough the number of exposed children in this study was too low to allow firm conclusions, results were more suggestive of an excess risk of leukemia among exposed children than of a null relation.

【 授权许可】

Unknown   
© Malagoli et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.