Vitamin D3receptor is highly expressed in Hodgkin’s lymphoma

BMC Cancer

Research Article

Martin L Hansmann¹  Christoph Renné¹  Alexander H Benz² 

[1] Senckenberg Institute of Pathology, University of Frankfurt, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany;Senckenberg Institute of Pathology, University of Frankfurt, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany;Department of Pathology, University of Giessen, Langhansstrasse 10, 35392, Gießen, Germany;

关键词: Follicular Lymphoma;    Hodgkin Lymphoma;    Nodular Lymphocyte Predominant Hodgkin Lymphoma;    Formalin Fixed Tissue;    Viral Latent Membrane Protein;   

DOI  :  10.1186/1471-2407-12-215

 received in 2012-03-03, accepted in 2012-05-25,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundHodgkin lymphoma (HL) is one of the most frequent lymphoma in the western world. Despite a good overall prognosis, some patients suffer relapsing tumors which are difficult to cure. Over a long period Vitamin D has been shown to be a potential treatment for cancer. Vitamin D acts via the vitamin D receptor, a nuclear receptor, acting as an inducible transcription factor. We aimed to investigate the expression of vitamin D receptor as a possible diagnostic marker and potential therapeutic target in HL as well as in B-cell derived non-Hodgkin lymphoma (B-NHL).MethodsWe used a panel of 193 formalin fixed tissues of lymphoma cases consisting of 55 cases of HL and 138 cases on several B-NHL entities.ResultsVitamin D receptor is strongly expressed in tumor cells of HL, regardless of the sub entity with an overall positivity of 80% of all HL cases. In contrast, only about 17% of the analyzed origin-NHL showed positivity for vitamin D receptor. The detection of nuclear localization of vitamin D receptor in the tumor cells of HL suggests activated status of the vitamin D receptor.ConclusionsOur study suggests VDR as a specific marker for tumor cells of HL, but not of B-NHL subtypes. Further, the observed nuclear localization suggests an activated receptor status in tumor cells of HL. Further investigations of mutational status and functional studies may shed some light in functional relevance of vitamin D receptor signaling in HL.

【 授权许可】

Unknown   
© Renne et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.