Parental urinary biomarkers of preconception exposure to bisphenol A and phthalates in relation to birth outcomes

Environmental Health

Research

Kurunthachalam Kannan¹  Germaine M. Buck Louis²  José M. Maisog²  Katherine L. Grantz²  Rajeshwari Sundaram²  Melissa M. Smarr² 

[1] Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health and Department of Environmental Health Sciences, The University at Albany, P.O. Box 509, Empire State Plaza, Albany, NY, USA;Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd, 20852, Rockville, MD, USA;

关键词: Bisphenol A;    Phthalates;    Preconception exposure;    Birth weight;    Head circumference;    Ponderal index;    Endocrine disruptors;   

DOI  :  10.1186/s12940-015-0060-5

 received in 2015-05-13, accepted in 2015-09-01,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundBisphenol A (BPA) and phthalates are ubiquitous non-persistent endocrine disrupting chemicals whose relation with infant birth size is not clearly understood.MethodsWe examined associations between maternal and paternal preconception urinary concentrations of total BPA and 14 phthalate metabolites and birth size for 233 infants. Multiple linear regression models were used to estimate parental quartiles of BPA and phthalates in relation to birth weight, length, head circumference, and ponderal index with separate models run for each parent adjusting for age, smoking, body mass index, education, alcohol, parity, and creatinine. Models also included an interaction term for each chemical and infant sex and were further adjusted to include the other partner’s chemical concentrations.ResultsIn maternal models adjusted for partner’s exposure and covariates, reductions in birth weight (range: 178-215 g; p < 0.05) were observed for the 2nd quartile of maternal monomethyl phthalate, mono-[(2-carboxymethyl) hexyl] phthalate and mono-n-octyl phthalate when compared with the 1st quartiles. The 3rd quartile of monoethylhexyl phthalate (mEHP) was also associated with a 200.16 g (95 % CI: -386.90, -13.42) reduction. Similar reductions in birth weight were observed for the 2nd quartile of paternal mEHP (β = -191.93 g; 95 % CI: -381.61, -2.25). Additionally, select maternal urinary metabolites were associated with decreased head circumference, birth length and gestational age. However, paternal concentrations were generally associated with increased birth length and gestational age.ConclusionsWe observed some suggestion that preconception maternal and paternal urinary concentration of BPA and specific phthalate metabolites may be associated with smaller birth size and increased gestational age, though the findings appeared to be parent and chemical specific.

【 授权许可】

CC BY   
© Smarr et al. 2015