Olfactory coding from the periphery to higher brain centers in the Drosophila brain

BMC Biology

Research Article

Bill S. Hansson¹  Silke Sachse¹  Jürgen Rybak¹  Dieter Wicher¹  Hany K. M. Dweck²  Yoichi Seki³ 

[1] Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans-Knöll-Strasse 8, 07745, Jena, Germany;Present address: Department of Molecular, Cellular, and Developmental Biology, Yale University, 06520, New Haven, CT, USA;Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans-Knöll-Strasse 8, 07745, Jena, Germany;Present address: Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, 192-0392, Tokyo, Japan;Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans-Knöll-Strasse 8, 07745, Jena, Germany;

关键词: Drosophila melanogaster;    Insect olfaction;    Antennal lobe;    Mushroom body;    Lateral horn;    Whole cell patch-clamp;   

DOI  :  10.1186/s12915-017-0389-z

 received in 2017-04-15, accepted in 2017-06-02,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundOdor information is processed through multiple receptor-glomerular channels in the first order olfactory center, the antennal lobe (AL), then reformatted into higher brain centers and eventually perceived by the fly. To reveal the logic of olfaction, it is fundamental to map odor representations from the glomerular channels into higher brain centers.ResultsWe characterize odor response profiles of AL projection neurons (PNs) originating from 31 glomeruli using whole cell patch-clamp recordings in Drosophila melanogaster. We reveal that odor representation from olfactory sensory neurons to PNs is generally conserved, while transformation of odor tuning curves is glomerulus-dependent. Reconstructions of PNs reveal that attractive and aversive odors are represented in different clusters of glomeruli in the AL. These separate representations are preserved into higher brain centers, where attractive and aversive odors are segregated into two regions in the lateral horn and partly separated in the mushroom body calyx.ConclusionsOur study reveals spatial representation of odor valence coding from the AL to higher brain centers. These results provide a global picture of the olfactory circuit design underlying innate odor-guided behavior.

【 授权许可】

CC BY   
© Seki et al. 2017