Changing patterns of malaria during 1996-2010 in an area of moderate transmission in Southern Senegal

Malaria Journal

Research

Malick Badiane¹  Philippe Brasseur²  Patrice Agnamey³  Michel T Vaillant⁴  Moustafa Cisse⁵  Piero L Olliaro⁶ 

[1] District Médical d'Oussouye, Oussouye, Sénégal;Institut de Recherche pour le Développement (IRD), UMR 198, Rue Wagane Diouf × Georges Pompidou, Dakar, Sénégal;Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, Place Victor Pauchet, 80054, Amiens, France;Methodology and Statistical Unit, Center for Health Studies, CRP Santé, 1a Rue Thomas Edison, L-1445, Strassen, Luxembourg;Unité 3677, Bases thérapeutiques des inflammations et infections, Université Victor Segalen Bordeaux 2, 145 Rue Leo Saignat, 33000, Bordeaux, France;Programme National de Lutte contre le Paludisme (PNLP), Ministère de la Santé et de la Prévention, BP. 4024, Rue Aimé Césaire, Dakar, Sénégal;UNICEF/UNDP/WB/WHO Special Programme for Research & Training in Tropical Diseases (TDR), 20 avenue Appia, CH-1211, Geneva 27, Switzerland;Centre for Tropical Medicine and Vaccinology, Nuffield Department of Medicine, University of Oxford, OX3, Churchill Hospital, Oxford, UK;

关键词: Malaria;    Malaria Case;    Rapid Diagnostic Test;    Malaria Treatment;    Entomological Inoculation Rate;   

DOI  :  10.1186/1475-2875-10-203

 received in 2011-04-05, accepted in 2011-07-25,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundMalaria is reportedly receding in different epidemiological settings, but local long-term surveys are limited. At Mlomp dispensary in south-western Senegal, an area of moderate malaria transmission, year-round, clinically-suspected malaria was treated with monotherapy as per WHO and national policy in the 1990s. Since 2000, there has been a staggered deployment of artesunate-amodiaquine after parasitological confirmation; this was adopted nationally in 2006.MethodsData were extracted from clinic registers for the period between January 1996 and December 2010, analysed and modelled.ResultsOver the 15-year study period, the risk of malaria decreased about 32-times (from 0.4 to 0.012 episodes person-year), while anti-malarial treatments decreased 13-times (from 0.9 to 0.07 treatments person-year) and consultations for fever decreased 3-times (from 1.8 to 0.6 visits person-year). This was paralleled by changes in the age profile of malaria patients so that the risk of malaria is now almost uniformly distributed throughout life, while in the past malaria used to concern more children below 16 years of age.ConclusionsThis study provides direct evidence of malaria risk receding between 1996-2010 and becoming equal throughout life where transmission used to be moderate. Infection rates are no longer enough to sustain immunity. Temporally, this coincides with deploying artemisinin combinations on parasitological confirmation, but other contributing causes are unclear.

【 授权许可】

Unknown   
© Brasseur et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.