Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris

Cardiovascular Diabetology

Original Investigation

Byung-Soo Youn¹  Soon Young Hwang²  Hong Seog Seo³  Hye Jin Yoo⁴  Hae Yoon Choi⁴  Ho Chel Hong⁴  Kyung Mook Choi⁴  Sei Hyun Baik⁴ 

[1] AdipoGen, Inc, Venture Building B, Songdo Technopark, 7-50 Songdo-dong, Yeonsu-gu, Incheon, Korea;Department of Biostatistics, College of Medicine, Korea University, Seoul, Korea;Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 80 Guro-Dong, 152-050, Guro-Gu, Seoul, Korea;Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea;

关键词: C1q/tumor necrosis factor-related protein-3;    Progranulin;    Coronary artery disease;    Acute coronary syndrome;    Stable angina pectoris;    Adipokines;   

DOI  :  10.1186/1475-2840-13-14

 received in 2013-11-20, accepted in 2014-01-10,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundC1q/TNF-related protein-3 (CTRP-3), an adiponectin paralog, and progranulin were recently identified as novel adipokines which may link obesity with glucose dysregulation and subclinical inflammation. We analyzed the relationship between CTRP-3, progranulin and coronary artery disease (CAD) in Korean men and women.MethodsCirculating CTRP-3 and progranulin levels were examined in 362 Korean adults with acute coronary syndrome (ACS, n = 69), stable angina pectoris (SAP, n = 85), and control subjects (n = 208) along with various kinds of cardiometabolic risk factors.ResultsCTRP-3 concentrations were significantly decreased in patients with ACS or SAP compared to control subjects (P <0.001, respectively), whereas progranulin and adiponectin levels were similar. Correlation analysis adjusted for age and gender exhibited that CTRP-3 levels showed significant negative relationship with glucose (r = -0.110, P = 0.041) and high sensitive C-reactive protein (hsCRP) levels (r = -0.159, P = 0.005), and positive relationship with HDL-cholesterol (r = 0.122, P = 0.025) and adiponectin levels (r = 0.194, P <0.001). In a multivariate logistic regression analysis, the odds ratio for CAD risk was 5.14 (95% CI, 1.83-14.42) in the second, and 9.04 (95% CI, 2.81-29.14) in the first tertile of CTRP-3 levels compared to third tertile after adjusting for other cardiometabolic risk variables.ConclusionsPatients with ACS or SAP had significantly lower circulating CTRP-3 concentrations compared to control subjects, although progranulin levels were not different. These results suggest the possibility that CTRP-3 might be useful for assessing the risk of CAD.Trial registration(Clinical trials No.: NCT01594710)

【 授权许可】

Unknown   
© Choi et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.