Evaluation of lipase levels in patients with nephropathia epidemica - no evidence for acute pancreatitis

BMC Infectious Diseases

Research Article

Ferruh Artunc¹  Joerg Latus²  Daniel Kitterer²  Niko Braun²  M. Dominik Alscher²  Stephan Segerer³ 

[1] Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tuebingen, Tuebingen, Germany;Department of Internal Medicine, Division of General Medicine and Nephrology, Robert-Bosch-Hospital, Auerbachstr. 110, 70376, Stuttgart, Germany;Division of Nephrology, University Hospital, Zurich, Switzerland;

关键词: Hantavirus;    Puumala virus;    HFRS;    Nephopathia epidemica;    Pancreatitis;    Lipase;   

DOI  :  10.1186/s12879-015-1031-8

 received in 2015-03-16, accepted in 2015-07-16,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe most common causative agent for hemorrhagic fever with renal syndrome in Germany is Puumala virus (PUUV) and a high percentage of patients with PUUV infection have gastrointestinal (GI) symptoms. The aim of the present study was to determine the prevalence of increased lipase levels and acute pancreatitis during nephropathia epidemica (NE) in 166 patients from Germany.MethodsClinical and laboratory data during the acute phase of the disease were obtained from medical reports and files from 456 patients during acute hantavirus infection. Patients in whom serum lipase levels were determined during acute course of the disease were included in the study.ResultsLipase levels at the time of diagnosis were determined in 166 of the 456 NE patients (36 %). Of the 166 patients, 25 (15 %) had elevated lipase levels at the time of admission to hospital or first contact with general practitioner/nephrologist. In total 7 patients had a threefold increased serum lipase above the normal range. Abdominal pain was not more often present in the group of patients with elevated serum lipase compared to the lipase-negative group (9/25 vs 58/141). Abdominal ultrasound and CT scans revealed no signs of pancreatitis in any of the patients. Patients with elevated serum lipase had higher serum creatinine peak levels (p = 0.03) during the course of the disease.ConclusionsElevated lipase levels were common in our patient cohort and might reflect a more severe form of NE. NE does not lead to acute pancreatitis.

【 授权许可】

Unknown   
© Kitterer et al. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.