Comparison of serum apolipoprotein A-I between Chinese multiple sclerosis and other related autoimmune disease

Lipids in Health and Disease

Research

Cong Gao¹  ShuXiang Pu¹  BinMei Li¹  Bin Zhang¹  JianRui Ying¹  Xing Wang Song¹ 

[1] Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, The Second Affiliated Hospital of GuangZhou Medical University, 250# Changgang east Road, 510260, GuangZhou, Guangdong Province, China;Institute of Neuroscience, Department of Neurology, The Second Affiliated Hospital of GuangZhou Medical University, 250# Changgang east Road, 510260, GuangZhou, Guangdong Province, China;

关键词: Multiple Sclerosis;    Systemic Lupus Erythematosus;    Multiple Sclerosis Patient;    Systemic Lupus Erythematosus Patient;    Expand Disability Status Scale;   

DOI  :  10.1186/1476-511X-9-34

 received in 2010-02-24, accepted in 2010-03-29,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundSerum apolipoprotein (apo) A-I was considered to be an immune regulator and could suppress pro-inflammatory cytokines generated by activated T cell in some autoimmune diseases. However, the change of serum apoA-I levels in multiple sclerosis (MS) patients is unknown.MethodsIn the presentation we performed a study on serum apoA-I levels in the patients with MS. We enrolled some age and gender matched patients with MS, autoimmune demyelinating diseases (Guillain-Barre Syndrome and Clinically Isolated Syndrome), neuroinflammatory diseases (viral encephalitis), autoimmune connective diseases (rheumatoid arthritis and systemic lupus erythematosus) and healthy control groups, and tested their serum lipids levels: total cholesterol (TC), triglyceride (TG), high-density lipoproteins (HDL), apolipoproteinB100 (apoB100), apolipoproteinA-I (apoA-I).ResultsFor all patients, age had no effect on serum apoA-I levels (P > 0.05). Meanwhile, we proved the highest serum apoA-I levels in MS patients and the lowest serum apoA-I levels in SLE patients. Serum apoA-I levels was significantly elevated in female MS patients (P = 0.033; P < 0.05).ConclusionIn short we believed that patients with MS and other autoimmune demyelination had significantly decreased serum levels of apo A-I.

【 授权许可】

Unknown   
© Zhang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.