Micronutrients and pregnancy; effect of supplementation on pregnancy and pregnancy outcomes: a systematic review

Nutrition Journal

Review

Henok Taddese Ayele¹  Taddese Alemu Zerfu² 

[1] College of Health Sciences and Referral Hospital, Dilla University, Dilla, Ethiopia;Department of Infectious Diseases Epidemiology, Devision of Julius Center for Health Sciences & Primary Care, University Medical Center, Heidelberglaan 100, 3584, Utrecht, CX, The Netherlands;College of Health Sciences and Referral Hospital, Dilla University, Dilla, Ethiopia;Food Science and Nutrition Program, College of Natural Sciences, Addis Ababa University, Ethiopia;

关键词: Preterm Birth;    Birth Outcome;    Folic Acid Supplementation;    Pregnant Mother;    Micronutrient Supplementation;   

DOI  :  10.1186/1475-2891-12-20

 received in 2012-05-15, accepted in 2013-01-25,  发布年份 2013

来源: Springer

【 摘 要 】

IntroductionEvery year more than 20 million infants are born with low birth weight worldwide. About 3.6 million infants die during the neonatal period. More than one third of child deaths are thought to be attributable to maternal and child under nutrition.ObjectivesTo systematically review the effect of supplementing various combinations and types of micronutrients on the course and outcomes of pregnancy.MethodsElectronic search of Medline, Pub Med, Health Internetwork access to Research Initiative, and Google Scholar databases was conducted. Outcomes of interest were birth weight, low birth weight, small size for gestational age, prenatal mortality and neonatal mortality. After exclusion of irrelevant /incomplete ones, 17 out of 115 articles were considered for the final analysis.FindingsMajority of the articles reviewed favored the supplementation of micronutrients to pregnant mother. Some studies suggested calcium supplementation is associated with a significant protective benefit in the prevention of pre-eclampsia. The remaining articles reviewed, showed significant benefit of Multiple Micronutrients supplementation during pregnancy in reducing low birth weight, small for Gestational Age births as compared to the usual iron-folate supplements.ConclusionsSupplying micronutrients, mainly multiple micronutrients have beneficial effect in reducing the risk of low birth weight and other complications. Further studies at various combination and doses of micronutrient supplements are recommended.

【 授权许可】

CC BY   
© Zerfu and Ayele; licensee BioMed Central Ltd. 2013