Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysis

Chinese Medicine

Research

Mengqi Li¹  Sanhu Fan²  Youde Zheng²  Peng Tan³  Haozhou Huang⁴  Li Han⁵  Yurou Jiang⁵  Min Qiu⁵  Gefei Li⁵  Yifan Zhang⁵  Xuan Deng⁵  Dingkun Zhang⁵  Junzhi Lin⁶ 

[1]Pharmacy Department, Sichuan Nursing Vocational College, 610100, Chengdu, China

[2]Sanajon Pharmaceutical Group, 610000, Chengdu, China

[3]State Key Laboratory of Quality Evaluation of Traditional Chinese Medicine, Sichuan Academy of Traditional Chinese Medicine, 610041, Chengdu, China

[4]State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, 611137, Chengdu, China

[5]Meishan Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Meishan Traditional Chinese Medicine Hospital, 620010, Meishan, China

[6]State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of TCM, 611137, Chengdu, China

[7]TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, 610072, Chengdu, People’s Republic of China

关键词: Phyllanthus emblica;    Ellagic acid;    Gallic acid;    Drying method;    Resisting exercise fatigue effect;   

DOI  :  10.1186/s13020-023-00835-4

 received in 2023-07-04, accepted in 2023-09-09,  发布年份 2023

来源: Springer

【 摘 要 】

Polyphenols are the main component of Phyllanthus emblica (PE). However, polyphenols are so easy to transform that it is unknown that how drying methods driven by heating affect the anti-fatigue effect of PE. This manuscript investigated the effects of five drying methods on the chemical composition transformation and anti-fatigue of PE, and discussed the action mechanism. The results suggested that the anti-fatigue effect of PE with hot-air-dried at 100 °C was the best, which was as 1.63 times as that with freeze-drying. Ellagic acid (EA) may be a key component of PE in anti-fatigue, and its mechanism of action may be related to regulating intestinal microbiota, protecting mitochondria, and regulating energy metabolism. This study first revealed the thermal transformation of polyphenols in PE, found the most effective strategy for enhancing the anti-fatigue function, and explores its action mechanism.

【 授权许可】

CC BY   
© International Society for Chinese Medicine and BioMed Central Ltd. 2023

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