Macrophage activation and polarization in post-infarction cardiac remodeling

Journal of Biomedical Science

Review

Vladimir Shurupov¹  Sergey V. Popov¹  Yuliya Rogovskaya²  Mariya Rebenkova²  Aleksandra Gombozhapova²  Vyacheslav Ryabov³  Rostislav S. Karpov⁴  Julia Kzhyshkowska⁵ 

[1] Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk 111a Kievskaya Street, 634012, Tomsk, Russian Federation;Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk 111a Kievskaya Street, 634012, Tomsk, Russian Federation;National Research Tomsk State University, 36 Lenin Avenue, 634050, Tomsk, Russian Federation;Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk 111a Kievskaya Street, 634012, Tomsk, Russian Federation;National Research Tomsk State University, 36 Lenin Avenue, 634050, Tomsk, Russian Federation;Siberian State Medical University, 2 Moscovsky trakt, 634055, Tomsk, Russian Federation;Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk 111a Kievskaya Street, 634012, Tomsk, Russian Federation;Siberian State Medical University, 2 Moscovsky trakt, 634055, Tomsk, Russian Federation;National Research Tomsk State University, 36 Lenin Avenue, 634050, Tomsk, Russian Federation;University of Heidelberg, 1-3 Theodor-Kutzer Ufer, 68167, Mannheim, Germany;

关键词: Myocardial infarction;    Inflammation;    Macrophages;    Monocytes;    Remodeling;    Heart failure;   

DOI  :  10.1186/s12929-017-0322-3

 received in 2016-10-12, accepted in 2017-01-31,  发布年份 2017

来源: Springer

【 摘 要 】

Adverse cardiac remodeling leads to impaired ventricular function and heart failure, remaining a major cause of mortality and morbidity in patients with acute myocardial infarction. It have been shown that, even if all the recommended therapies for ST-segment elevation myocardial infarction are performed, one third of patients undergoes progressive cardiac remodeling that represents morphological basis for following heart failure. The need to extend our knowledge about factors leading to different clinical scenarios of myocardial infarction and following complications has resulted in a research of immuno-inflammatory pathways and molecular activities as the basis for post-infarction remodeling. Recently, macrophages (cells of the innate immune system) have become a subject of scientific interest under both normal and pathological conditions. Macrophages, besides their role in host protection and tissue homeostasis, play an important role in pathophysiological processes induced by myocardial infarction. In this article we summarize data about the function of monocytes and macrophages plasticity in myocardial infarction and outline potential role of these cells as effective targets to control processes of inflammation, cardiac remodeling and healing following acute coronary event.

【 授权许可】

CC BY   
© The Author(s). 2017