Italian Journal of Pediatrics | |
Severity of SARS-CoV-2 infection in a hospital population: a clinical comparison across age groups | |
Research | |
Antonio Muscatiello1  Laura Alagna1  Alessandra Bandera2  Fabiana Ciciriello3  Vincenzina Lucidi3  Andrea Gramegna4  Paola Giovanna Marchisio5  Paola Medino6  Chiara Rosazza6  Arianna Biffi6  Carla Colombo7  Sara Uceda Renteria8  | |
[1] Clinic of Infectious Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy;Clinic of Infectious Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy;Department of Pathophysiology and Transplantation, University of Milan, Via Commenda 9, 20122, Milan, Italy;Cystic Fibrosis Center, ‘Bambino Gesù’ Children’s Hospital, IRCCS, Rome, Italy;Department of Pathophysiology and Transplantation, University of Milan, Via Commenda 9, 20122, Milan, Italy;Internal Medicine Department, Respiratory Unit and Regional Adult Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy;Department of Pathophysiology and Transplantation, University of Milan, Via Commenda 9, 20122, Milan, Italy;Pediatria Pneumoinfettivologia, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy;Paediatric Cystic Fibrosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy;Paediatric Cystic Fibrosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy;Department of Pathophysiology and Transplantation, University of Milan, Via Commenda 9, 20122, Milan, Italy;Virology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; | |
关键词: COVID-19; SARS-CoV-2 infection; Paediatric population; MIS-C; Outcome; | |
DOI : 10.1186/s13052-023-01485-w | |
received in 2023-02-25, accepted in 2023-06-22, 发布年份 2023 | |
来源: Springer | |
【 摘 要 】
BackgroundChildren tend to have milder forms of COVID-19 than adults, however post-acute complications have been observed also in the paediatric population. In this study, we compared COVID-19-related outcomes and long-term complications between paediatric and adult patients infected by SARS-CoV-2.MethodsThe study is based on individuals enrolled from October 2020 to June 2021 in the DECO COVID-19 multicentre prospective study supported by the Italian Ministry of Health (COVID-2020–12371781). We included individuals with RT-PCR -confirmed SARS-CoV-2 infection, who were evaluated in the emergency department and/or admitted to COVID-dedicated wards. The severity of SARS-CoV-2 infection was compared across age groups (children/adolescents aged < 18 years, young/middle-aged adults aged 18–64 years and older individuals) through the relative risk (RR) of severe COVID-19. Severity was defined by: 1) hospitalization due to COVID-19 and/or 2) need or supplemental oxygen therapy. RR and corresponding 95% confidence intervals were estimated using log-binomial models.ResultsThe study included 154 individuals, 84 (54.5%) children/adolescents, 50 (32.5%) young/middle-aged adults and 20 (13%) older adults. Compared to young/middle-aged adults the risk of hospitalization was lower among paediatric patients (RR: 0.49, 95% CI: 0.32–0.75) and higher among older adults (RR: 1.52, 95% CI: 1.12–2.06). The RR of supplemental oxygen was 0.12 (95% CI: 0.05–0.30) among children/adolescents and 1.46 (95% CI: 0.97–2.19) among older adults. Three children developed multisystem inflammatory syndrome (MIS-C), none was admitted to intensive care unit or reported post-acute Covid-19 complications.ConclusionsOur study confirms that COVID-19 is less severe in children. MIS-C is a rare yet severe complication of SARS-CoV-2 infection in children and its risk factors are presently unknown.
【 授权许可】
CC BY
© Società Italiana di Pediatria 2023
【 预 览 】
Files | Size | Format | View |
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RO202311109121985ZK.pdf | 1221KB | download | |
12936_2023_4742_Article_IEq70.gif | 1KB | Image | download |
12951_2016_171_Article_IEq5.gif | 1KB | Image | download |
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【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]
- [17]
- [18]
- [19]
- [20]
- [21]
- [22]
- [23]
- [24]
- [25]
- [26]
- [27]
- [28]
- [29]
- [30]
- [31]
- [32]
- [33]
- [34]
- [35]
- [36]
- [37]
- [38]