Costs of delivering human papillomavirus vaccination to schoolgirls in Mwanza Region, Tanzania

BMC Medicine

Research Article

Fern Terris-Prestholt¹  Wilm Quentin²  David A Ross³  W John Edmunds³  Richard Hayes³  Raymond Hutubessy⁴  Selephina Soteli⁵  Deborah Watson-Jones⁶  Saidi Kapiga⁷  John Changalucha⁸ 

[1] Department of Global Health and Development, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, WC1H 9SH, London, UK;Department of Health Care Management, Berlin University of Technology, Straße des 17 Juni 135, 10623, Berlin, Germany;Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK;Initiative for Vaccines Research, World Health Organization, Avenue Appia, 1211, Geneva 27, Switzerland;Mwanza Intervention Trials Unit, National Institute for Medical Research, PO Box 11936, Mwanza, Tanzania;Mwanza Intervention Trials Unit, National Institute for Medical Research, PO Box 11936, Mwanza, Tanzania;Department of Clinical Research, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK;Mwanza Intervention Trials Unit, National Institute for Medical Research, PO Box 11936, Mwanza, Tanzania;Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT, London, UK;Mwanza Research Centre, National Institute for Medical Research, PO Box 1462, Mwanza, Tanzania;

关键词: Africa;    costs and cost analysis;    economics papillomavirus vaccines;    uterine cervical neoplasms;   

DOI  :  10.1186/1741-7015-10-137

 received in 2012-06-02, accepted in 2012-11-13,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundCervical cancer is the leading cause of female cancer-related deaths in Tanzania. Vaccination against human papillomavirus (HPV) offers a new opportunity to control this disease. This study aimed to estimate the costs of a school-based HPV vaccination project in three districts in Mwanza Region (NCT ID: NCT01173900), Tanzania and to model incremental scaled-up costs of a regional vaccination program.MethodsWe first conducted a top-down cost analysis of the vaccination project, comparing observed costs of age-based (girls born in 1998) and class-based (class 6) vaccine delivery in a total of 134 primary schools. Based on the observed project costs, we then modeled incremental costs of a scaled-up vaccination program for Mwanza Region from the perspective of the Tanzanian government, assuming that HPV vaccines would be delivered through the Expanded Programme on Immunization (EPI).ResultsTotal economic project costs for delivering 3 doses of HPV vaccine to 4,211 girls were estimated at about US$349,400 (including a vaccine price of US$5 per dose). Costs per fully-immunized girl were lower for class-based delivery than for age-based delivery. Incremental economic scaled-up costs for class-based vaccination of 50,290 girls in Mwanza Region were estimated at US$1.3 million. Economic scaled-up costs per fully-immunized girl were US$26.41, including HPV vaccine at US$5 per dose. Excluding vaccine costs, vaccine could be delivered at an incremental economic cost of US$3.09 per dose and US$9.76 per fully-immunized girl. Financial scaled-up costs, excluding costs of the vaccine and salaries of existing staff were estimated at US$1.73 per dose.ConclusionsProject costs of class-based vaccination were found to be below those of age-based vaccination because of more eligible girls being identified and higher vaccine uptake. We estimate that vaccine can be delivered at costs that would make HPV vaccination a very cost-effective intervention. Potentially, integrating HPV vaccine delivery with cost-effective school-based health interventions and a reduction of vaccine price below US$5 per dose would further reduce the costs per fully HPV-immunized girl.

【 授权许可】

CC BY   
© Quentin et al; licensee BioMed Central Ltd. 2012