Clinical trial of extended-dose chloroquine for treatment of resistant falciparum malaria among Afghan refugees in Pakistan

Malaria Journal

Research

Naeem Durrani¹  Sanda Sanda²  Natasha Howard²  Rachel Hallett²  Khalid Beshir²  Mark Rowland³ 

[1] HealthNet-TPO, Peshawar, Pakistan and Kabul Afghanistan;London School of Hygiene and Tropical Medicine (LSHTM), London, UK;London School of Hygiene and Tropical Medicine (LSHTM), London, UK;HealthNet-TPO, Peshawar, Pakistan and Kabul Afghanistan;

关键词: Malaria;    Chloroquine;    Falciparum Malaria;    Vivax Malaria;    Parasite Clearance Time;   

DOI  :  10.1186/1475-2875-10-171

 received in 2010-12-13, accepted in 2011-06-23,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundFalciparum malaria is a significant problem for Afghan refugees in Pakistan. Refugee treatment guidelines recommended standard three-day chloroquine treatment (25 mg/kg) for first episodes and extended five-day treatment (40 mg/kg) for recrudescent infections, based on the assumption that a five-day course would more likely achieve a cure. An in-vivo randomized controlled trial was conducted among refugees with uncomplicated falciparum malaria to determine whether five-day treatment (CQ40) was more effective than standard treatment (CQ25).Methods142 falciparum patients were recruited into CQ25 or CQ40 treatment arms and followed up to 60 days with regular blood smears. The primary outcome was parasitological cure without recrudescence. Treatment failures were retreated with CQ40. PCR genotyping of 270 samples, from the same and nearby sites, was used to support interpretation of outcomes.Results84% of CQ25 versus 51% of CQ40 patients experienced parasite recrudescence during follow-up (adjusted odds ratio 0.17, 95%CI 0.08-0.38). Cure rates were significantly improved with CQ40, particularly among adults. Fever clearance time, parasite clearance time, and proportions gametocytaemic post-treatment were similar between treatment groups. Second-line CQ40 treatment resulted in higher failure rates than first-line CQ40 treatment. CQ-resistance marker pfcrt 76T was found in all isolates analysed, while pfmdr1 86Y and 184Y were found in 18% and 37% of isolates respectively.ConclusionsCQ is not suitable for first-line falciparum treatment in Afghan refugee communities. The extended-dose CQ regimen can overcome 39% of resistant infections that would recrudesce under the standard regimen, but the high failure rate after directly observed treatment demonstrates its use is inappropriate.

【 授权许可】

CC BY   
© Howard et al; licensee BioMed Central Ltd. 2011