World Journal of Surgical Oncology | |
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature | |
Research | |
Sinan Wang1  Hongyuan Zhou2  Yunlong Cui2  Qiang Li2  Lun Zhang3  Yu Wang3  Xuan Zhou3  | |
[1] Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China;Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute, National Clinical Research Center of Cancer, 300060, Tianjin, China;The Department of Maxillofacial and Otorhinolaryngology Oncology, Tianjin Medical University Cancer Institute & Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute, National Clinical Research Center of Cancer, 300060, Tianjin, China; | |
关键词: Pancreatic cancer; Acinar cell carcinoma; Resection; Surgery; Pancreatectomy; Pancreas; | |
DOI : 10.1186/s12957-016-0919-0 | |
received in 2015-11-27, accepted in 2016-06-15, 发布年份 2016 | |
来源: Springer | |
【 摘 要 】
BackgroundAcinar cell carcinoma (ACC) is a relatively rare pancreatic neoplasm with poorly defined prognosis. This study aimed to investigate this rare pancreatic neoplasm through comparing patients with ACC to pancreatic ductal cell adenocarcinoma (DCA).MethodsTianjin Medical University Cancer Institute and Hospital pathology database was reviewed from 1995 to 2015, and 19 patients with pathologically confirmed ACC were enrolled while 19 conventional DCA patients assigned randomly as control. Retrospective review and follow-up were performed for each patient. Regression methods were used to identify differences between ACC and DCA.ResultsIn our study, most patients suffered from abdominal or back pain, and no lipase hypersecretion syndrome was observed. For ACC, resected cases had better survival than those without resection, and earlier staging was related to longer survival. Resection with postoperative adjuvant therapy had a better outcome than surgery alone. Twelve cases developed recurrence. Compared to DCA, ACC had earlier staging and better survival. The overall 1-, 2-, and 5-year survival rates for patients with ACC were 73.7, 26.3, and 5 %, respectively.ConclusionsACC carries a better prognosis than DCA and a similarly high recurrence rate, while surgical resection proved the best first-line approach for it. A well-planned neoadjuvant or adjuvant chemoradiotherapy indeed benefit the patients with ACC.
【 授权许可】
CC BY
© The Author(s). 2016
【 预 览 】
Files | Size | Format | View |
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RO202311109036920ZK.pdf | 825KB | download |
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