African ancestry is associated with facial melasma in women: a cross-sectional study

BMC Medical Genetics

Research Article

Hélio Amante Miot¹  Maria Paula Barbieri D’Elia¹  Luciane Donida Bartoli Miot¹  Marcela Calixto Brandão²  Márcia Guimarães da Silva²  Bruna Ribeiro de Andrade Ramos²  Sidney Emanuel Batista dos Santos³ 

[1] Department of Dermatology, FMB-Unesp, Botucatu, SP, Brazil;Department of Pathology, FMB-Unesp, Botucatu, SP, Brazil;Institute of Biological Sciences, UFPA, Belém, PA, Brazil;

关键词: Melasma;    Melanosis;    Contraceptives;    Oral contraceptives;    Pregnancy;    Hormones;    Gonadal steroid hormones;    Melanosis;    Pigmentation;    Skin pigmentation;    Ultraviolet rays;    Pigmentation disorders;    Ancestry;    INDEL;   

DOI  :  10.1186/s12881-017-0378-7

 received in 2015-11-12, accepted in 2017-02-03,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundMelasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Here, we evaluated the association between genetic ancestry and facial melasma.MethodsA cross-sectional study involving women with melasma and an age-matched control group from outpatients at FMB-Unesp, Botucatu-SP, Brazil was performed. DNA was extracted from oral mucosa swabs and ancestry determined by studying 61 INDELs. The genetic ancestry components were adjusted by other known risk factors by multiple logistic regression.ResultsWe evaluated 119 women with facial melasma and 119 controls. Mean age was 39 ± 9 years. Mean age at beginning of disease was 27 ± 8 years. Pregnancy (40%), sun exposure (37%), and hormonal oral contraception (22%) were the most frequently reported melasma triggers. All subjects presented admixed ancestry, African and European genetic contributions were significantly different between cases and controls (respectively 10% vs 6%; 77% vs 82%; p < 0.05). African ancestry (OR = 1.04; 95% CI 1.01 to 1.07), first generation family history (OR = 3.04; 95% CI 1.56 to 5.94), low education level (OR = 4.04; 95% CI 1.56 to 5.94), and use of antidepressants by individuals with affected family members (OR = 6.15; 95% CI 1.13 to 33.37) were associated with melasma, independently of other known risk factors.ConclusionsFacial melasma was independently associated with African ancestry in a highly admixed population.

【 授权许可】

CC BY   
© The Author(s). 2017