Tomato juice intake suppressed serum concentration of 8-oxodG after extensive physical activity

Nutrition Journal

Short Report

Dag Jenssen¹  Siamak Haghdoost¹  Mats Harms-Ringdahl¹ 

[1] Centre for Radiation Protection Research (CRPR), Department of Genetics, Microbiology and Toxicology, Stockholm University, SE-106 91, Stockholm, Sweden;

关键词: Reactive oxygen species;    ROS;    Free radicals;    Exercise;    Lycopene;    Tomato juice;    Life style;    ELISA;    hMTH1;    8-oxo-dG;   

DOI  :  10.1186/1475-2891-11-29

 received in 2011-11-02, accepted in 2012-04-09,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundDNA is constantly exposed to reactive oxygen species (ROS), spontaneously arising during the normal oxygen metabolism. ROS may result in temporary as well as permanent modifications in various cellular components such as lipids, proteins and DNA, which may have deleterious consequences. Demonstrating that a dietary supplementation of antioxidants can reduce oxidative DNA damage may provide evidence for the value of such supplementation in prevention of cancer and age related diseases.FindingsThe present study was conducted to address whether tomato juice protects against ROS induced by extensive physical exercise in untrained individuals. As a marker of oxidative stress, serum levels of 8-oxodG were monitored using a modified ELISA. An intervention was performed involving 15 untrained healthy subjects who performed a 20 min physical exercise at 80% of maximum pulse using an ergometer bicycle. Blood samples were taken before and one hour after the exercise. The procedure was repeated after 5 weeks with a daily intake of 150 ml tomato juice and followed by a 5 weeks wash-out period and another 5 weeks with a daily intake of tomato juice. The results indicated that a daily intake of tomato juice, equal to 15 mg lycopene per day, for 5 weeks significantly reduced the serum levels of 8-oxodG after an extensive physical exercise.ConclusionThese data strongly suggest that tomato juice has a potential antioxidant effect and may reduce the elevated level of ROS induced by oxidative stress.

【 授权许可】

Unknown   
© Harms-Ringdahl et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.