Genetic analyses of smoking initiation, persistence, quantity, and age-at-onset of regular cigarette use in Brazilian families: the Baependi Heart Study

BMC Medical Genetics

Research Article

Mariza de Andrade¹  Júlia P Soler²  Suely R Giolo³  José E Krieger⁴  Andréa RVR Horimoto⁴  Camila M Oliveira⁴  Alexandre C Pereira⁴ 

[1] Department of Health Sciences Research, Mayo Clinic, 200 First Street S.W., 55905, Rochester, MN, USA;Department of Statistics, Mathematics and Statistics Institute, University of São Paulo, R. do Matão, 1010, 05508-090, São Paulo, SP, Brazil;Department of Statistics, Polytechnic Center, Federal University of Paraná, Av. Cel. Francisco H. Santos, 100, 81531-990, Curitiba, PR, Brazil;Laboratory of Genetics and Molecular Cardiology, Heart Institute, Medical School of University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, 05403-000, São Paulo, SP, Brazil;

关键词: Variance Component;    Smoking Behavior;    Nicotine Dependence;    Heritability Estimate;    Familial Aggregation;   

DOI  :  10.1186/1471-2350-13-9

 received in 2011-06-29, accepted in 2012-01-30,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe purpose of this study was to estimate the genetic influences on the initiation of cigarette smoking, the persistence, quantity and age-at-onset of regular cigarette use in Brazilian families.MethodsThe data set consisted of 1,694 individuals enrolled in the Baependi Heart Study. The heritability and the heterogeneity in genetic and environmental variance components by gender were estimated from variance components approaches, using the SOLAR (Sequential Oligogenic Linkage Analysis Routines) computer package. The mixed-effects Cox model was used for the genetic analysis of the age-at onset of regular cigarette use.ResultsThe heritability estimates were high (> 50%) for smoking initiation and were intermediate, ranging from 23.4 to 31.9%, for smoking persistence and quantity. Significant evidence for heterogeneity in variance components by gender was observed for smoking initiation and age-at-onset of regular cigarette use. Genetic factors play an important role in the interindividual variation of these phenotypes in females, while in males there is a predominant environmental component, which could be explained by greater social influences in the initiation of tobacco use.ConclusionsSignificant heritabilities were observed in smoking phenotypes for both males and females from the Brazilian population. These data add to the literature and are concordant with the notion of significant biological determination in smoking behavior. Samples from the Baependi Heart Study may be valuable for the mapping of genetic loci that modulate this complex biological trait.

【 授权许可】

Unknown   
© Horimoto et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.