Prediction consistency and clinical presentations of breast cancer molecular subtypes for Han Chinese population

Journal of Translational Medicine

Proceedings

Chih-Yi Liu¹  Yih-Yiing Wu¹  Jaan-Yeh Jeng²  Eric Y Chuang³  Chi-Cheng Huang⁴  Liang-Chuan Lai⁵  Heng-Hui Lien⁶  Jung-Sen Liu⁶  Ching-Shui Huang⁷  Shih-Hsin Tu⁷ 

[1] Department of Pathology, Cathay General Hospital SiJhih, New Taipei City, Taiwan;Department of Surgery, Cathay General Hospital SiJhih, New Taipei City, Taiwan;School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan;School of Medicine, Taipei Medical University, Taipei City, Taiwan;Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei City, Taiwan;Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei City, Taiwan;Department of Surgery, Cathay General Hospital SiJhih, New Taipei City, Taiwan;School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan;School of Medicine, Taipei Medical University, Taipei City, Taiwan;Graduate Institute of Physiology, National Taiwan University, Taipei City, Taiwan;School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan;Department of Surgery, Cathay General Hospital, Taipei City, Taiwan;School of Medicine, Taipei Medical University, Taipei City, Taiwan;Department of Surgery, Cathay General Hospital, Taipei City, Taiwan;

关键词: Breast Cancer;    Molecular Subtype;    Intrinsic Subtype;    Intrinsic Signature;    Breast Cancer Molecular Subtype;   

DOI  :  10.1186/1479-5876-10-S1-S10

来源: Springer

【 摘 要 】

BackgroundBreast cancer is a heterogeneous disease in terms of transcriptional aberrations; moreover, microarray gene expression profiles had defined 5 molecular subtypes based on certain intrinsic genes. This study aimed to evaluate the prediction consistency of breast cancer molecular subtypes from 3 distinct intrinsic gene sets (Sørlie 500, Hu 306 and PAM50) as well as clinical presentations of each molecualr subtype in Han Chinese population.MethodsIn all, 169 breast cancer samples (44 from Taiwan and 125 from China) of Han Chinese population were gathered, and the gene expression features corresponding to 3 distinct intrinsic gene sets (Sørlie 500, Hu 306 and PAM50) were retrieved for molecular subtype prediction.ResultsFor Sørlie 500 and Hu 306 intrinsic gene set, mean-centring of genes and distance-weighted discrimination (DWD) remarkably reduced the number of unclassified cases. Regarding pairwise agreement, the highest predictive consistency was found between Hu 306 and PAM50. In all, 150 and 126 samples were assigned into identical subtypes by both Hu 306 and PAM50 genes, under mean-centring and DWD. Luminal B tended to show a higher nuclear grade and have more HER2 over-expression status than luminal A did. No basal-like breast tumours were ER positive, and most HER2-enriched breast tumours showed HER2 over-expression, whereas, only two-thirds of ER negativity/HER2 over-expression tumros were predicted as HER2-enriched molecular subtype. For 44 Taiwanese breast cancers with survival data, a better prognosis of luminal A than luminal B subtype in ER-postive breast cancers and a better prognosis of basal-like than HER2-enriched subtype in ER-negative breast cancers was observed.ConclusionsWe suggest that the intrinsic signature Hu 306 or PAM50 be used for breast cancers in the Han Chinese population during molecular subtyping. For the prognostic value and decision making based on intrinsic subtypes, further prospective study with longer survival data is needed.

【 授权许可】

Unknown   
© Huang et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.