Incidence of medically attended influenza among residents of Shai-Osudoku and Ningo-Prampram Districts, Ghana, May 2013 – April 2015

BMC Infectious Diseases

Research Article

Jazmin Duque¹  Michael Adjabeng²  Erica Dueger³  Marc-Alain Widdowson³  Ndahwouh Talla Nzussouo⁴  Fatimah S. Dawood⁵  Meredith L. McMorrow⁵  Edem Badji⁶  Eve-Marie Benson⁶  Joseph Asamoah Frimpong⁶  Michael Preko Ntiri⁶  Kwadwo Koram⁶  William Ampofo⁶  Prince Parbie⁶ 

[1] Battelle Atlanta, Atlanta, Georgia, USA;Influenza Division, National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS-A32, 30329, Atlanta, GA, USA;Ghana Health Service, Accra, Ghana;Influenza Division, National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS-A32, 30329, Atlanta, GA, USA;Influenza Division, National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS-A32, 30329, Atlanta, GA, USA;CTS Global Inc, El Segundo, California, USA;Influenza Division, National Center for Immunization and Respiratory Diseases, U.S. Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS-A32, 30329, Atlanta, GA, USA;U.S. Public Health Service, Rockville, Maryland, USA;Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana;

关键词: Influenza;    Respiratory;    Burden;    Rate;    Children;    Ghana;    West Africa;    Africa;   

DOI  :  10.1186/s12879-016-2078-x

 received in 2016-06-21, accepted in 2016-11-29,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundInfluenza vaccination is recommended by the World Health Organization for high risk groups, yet few data exist on influenza disease burden in West Africa.MethodsWe estimated medically attended influenza-associated illness rates among residents of Shai-Osudoku and Ningo Pram-Pram Districts (SONPD), Ghana. From May 2013 to April 2015, we conducted prospective surveillance for severe acute respiratory illness (SARI) and influenza-like illness (ILI) in 17 health facilities. In 2015, we conducted a retrospective assessment at an additional 18 health facilities to capture all SONPD SARI and ILI patients during the study period. We applied positivity rates to those not tested to estimate total influenza cases.ResultsOf 612 SARI patients tested, 58 (9%) were positive for influenza. The estimated incidence of influenza-associated SARI was 30 per 100,000 persons (95% CI: 13-84). Children aged 0 to 4 years had the highest influenza-associated SARI incidence (135 per 100,000 persons, 95% CI: 120-152) and adults aged 25 to 44 years had the lowest (3 per 100,000 persons, 95% CI: 1-7) (p < 0.01). Of 2,322 ILI patients tested, 407 (18%) were positive for influenza. The estimated incidence of influenza-associated ILI was 844 per 100,000 persons (95% CI: 501-1,099). The highest incidence of influenza-associated ILI was also among children aged 0 to 4 years (3,448 per 100,000 persons, 95% CI: 3,727 – 3,898). The predominant circulating subtype during May to December 2013 and January to April 2015 was influenza A(H3N2) virus, and during 2014 influenza B virus was the predominant circulating type.ConclusionsInfluenza accounted for 9% and 18% of medically attended SARI and ILI, respectively. Rates were substantive among young children and suggest the potential value of exploring the benefits of influenza vaccination in Ghana, particularly in this age group.

【 授权许可】

CC BY   
© The Author(s). 2016