CircRNA: functions and properties of a novel potential biomarker for cancer

Molecular Cancer

Review

Shujuan Meng¹  Hecheng Zhou¹  Zihao Xu¹  Ying Tang¹  Ziyang Feng¹  Peiyao Li²  Minghua Wu² 

[1] Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, 410013, Changsha, Hunan, China;The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, 410008, Changsha, Hunan, China;The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, 410008, Changsha, Hunan, China;

关键词: circRNA;    Non-coding RNA;    microRNA sponge;    Tumour;    Biomarker;   

DOI  :  10.1186/s12943-017-0663-2

 received in 2017-02-18, accepted in 2017-05-16,  发布年份 2017

来源: Springer

【 摘 要 】

Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5′ cap or a 3′ Poly A tail. Although the mechanisms of circular RNAs’ generation and function are not fully clear, recent research has shown that circular RNAs may function as potential molecular markers for disease diagnosis and treatment and play an important role in the initiation and progression of human diseases, especially in tumours. This review summarizes some information about categories, biogenesis, functions at the molecular level, properties of circular RNAs and the possibility of circular RNAs as biomarkers in cancers.

【 授权许可】

CC BY   
© The Author(s). 2017