MDRD or CKD-EPI study equations for estimating prevalence of stage 3 CKD in epidemiological studies: which difference? Is this difference relevant?

BMC Nephrology

Research Article

Etienne Cavalier¹  Christophe Mariat²  Nicolas Maillard²  Pierre Delanaye³  Jean-Marie Krzesinski³ 

[1] Department of Clinical Chemistry, University of Liège, CHU Sart Tilman, Liège, Belgium;Department of Nephrology, Dialysis and Transplantation, University of Saint-Etienne, Hopital Nord, Saint-Etienne, France;Department of Nephrology-Dialysis-Transplantation, University of Liège, CHU Sart Tilman, Liège, Belgium;

关键词: Chronic Kidney Disease;    Glomerular Filtration Rate;    Study Equation;    Glomerular Filtration Rate Estimation;    Chronic Kidney Disease Prevalence;   

DOI  :  10.1186/1471-2369-11-8

 received in 2009-09-21, accepted in 2010-06-01,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundPrevalence of stage 3 chronic kidney disease (CKD) is increasing according to the NHANES study. Prevalence has been calculated using the MDRD study equation for estimating glomerular filtration rate (GFR). Recently, a new estimator based on creatinine, the CKD-EPI equation, has been proposed which is presumed to better perform in normal GFR ranges. The aim of the study was to measure the difference in prevalence of stage 3 CKD in a population using either the MDRD or the CKD-EPI study equations.MethodsCKD screening is organized in the Province of Liège, Belgium. On a voluntary basis, people aged between 45 and 75 years are invited to be screened. GFR is estimated by the MDRD study equation and by the "new" CKD-EPI equations.ResultsThe population screened consisted in 1992 people (47% of men). Mean serum creatinine was 0.86 ± 0.20 mg/dL. The prevalence of stage 3 CKD in this population using the MDRD or the CKD-EPI equations was 11.04 and 7.98%, respectively. The prevalence of stage 3 CKD is significantly higher with the MDRD study equation (p < 0,0012).ConclusionsPrevalence of stage 3 CKD varies strongly following the method used for estimating GFR, MDRD or CKD-EPI study equations. Such discrepancies are of importance and must be confirmed and explained by additional studies using GFR measured with a reference method.

【 授权许可】

CC BY   
© Delanaye et al; licensee BioMed Central Ltd. 2010