Comparison of intraoperative blood loss during spinal surgery using either remifentanil or fentanyl as an adjuvant to general anesthesia

BMC Anesthesiology

Research Article

Eisuke Hamaguchi¹  Tomomi Matsumoto¹  Hiroaki Kawano²  Sawa Manabe³  Fumihiko Tada³  Michiko Kinoshita⁴  Shuzo Oshita⁵ 

[1] Department of Anesthesiology and Clinical Research, National Hospital Organization Zentsuji Hospital, Zentsuji, Japan;Department of Anesthesiology and Clinical Research, National Hospital Organization Zentsuji Hospital, Zentsuji, Japan;Department of Anesthesiology, Tokushima Prefectural Central Hospital, Tokushima, Japan;Department of Anesthesiology, Kagawa National Children’s Hospital, Zentsuji, Japan;Department of Anesthesiology, Tokushima Prefectural Central Hospital, Tokushima, Japan;Department of Anesthesiology, Tokushima University Hospital, Tokushima, Japan;

关键词: Intraoperative blood loss;    Remifentanil;    Hemodynamics;    Fentanyl;    Spinal surgery;    General anesthesia;   

DOI  :  10.1186/1471-2253-13-46

 received in 2013-07-06, accepted in 2013-11-21,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundRemifentanil enhances intraoperative hemodynamic stability, suggesting that it may decrease intraoperative blood loss when included as an adjuvant to general anesthesia. This retrospective study compared intraoperative blood loss during spinal surgery in patients administered either remifentanil or fentanyl as an opioid adjuvant.MethodsWe reviewed clinical and surgical data from 64 consecutive laminoplasty or laminectomy patients treated at National Hospital Organization Zentsuji Hospital between April 2010 and March 2011. Patients received either remifentanil (n = 35) or fentanyl (n = 29) as an opioid analgesic during general anesthesia. In addition to intraoperative blood loss, indices of hemodynamic stability, including heart rate as well as systolic, mean, and diastolic blood pressure (BP), were compared over the entire perioperative period between remifentanil and fentanyl groups.ResultsThe remifentanil group exhibited significantly lower intraoperative arterial BP than the fentanyl group. Intraoperative blood loss was also significantly lower in the remifentanil group (125 ± 67 mL vs. 165 ± 82 mL, P = 0.035).ConclusionsIntraoperative blood loss during spinal surgery was decreased in patients who received remifentanil as an opioid adjuvant, possibly because of lower intraoperative BP. A larger-scale prospective randomized controlled trial is warranted to confirm our results and to test whether remifentanil can decrease intraoperative blood loss during other surgical procedures.

【 授权许可】

CC BY   
© Kawano et al.; licensee BioMed Central Ltd. 2013