Causal associations between sleep traits and brain structure: a bidirectional Mendelian randomization study

Behavioral and Brain Functions

Research

Lei Qi¹  Guangyuan Jin¹  Liankun Ren¹  Di Wu¹  Xiaopeng Wang¹  Yuke Wang¹  Qiao Wang¹  Shimin Hu² 

[1] Department of Neurology, Xuanwu Hospital, Capital Medical University, NO.45 Changchun Street, Xicheng District, Beijing, China;National Center for Neurological Disorders, Beijing, China;Department of Neurology, Xuanwu Hospital, Capital Medical University, NO.45 Changchun Street, Xicheng District, Beijing, China;National Center for Neurological Disorders, Beijing, China;Beijing Key Laboratory of Neuromodulation, Beijing, China;Institute of Sleep and Consciousness Disorders, Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China;

关键词: Sleep hygiene;    Brain structure;    Mendelian randomization;    Causal effect;    Epidemiology;   

DOI  :  10.1186/s12993-023-00220-z

 received in 2023-05-16, accepted in 2023-09-28,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundEmerging evidence suggests bidirectional causal relationships between sleep disturbance and psychiatric disorders, but the underlying mechanisms remain unclear. Understanding the bidirectional causality between sleep traits and brain imaging-derived phenotypes (IDPs) will help elucidate the mechanisms. Although previous studies have identified a range of structural differences in the brains of individuals with sleep disorders, it is still uncertain whether grey matter (GM) volume alterations precede or rather follow from the development of sleep disorders.ResultsAfter Bonferroni correction, the forward MR analysis showed that insomnia complaint remained positively associated with the surface area (SA) of medial orbitofrontal cortex (β, 0.26; 95% CI, 0.15–0.37; P = 5.27 × 10–6). In the inverse MR analysis, higher global cortical SA predisposed individuals less prone to suffering insomnia complaint (OR, 0.89; 95%CI, 0.85–0.94; P = 1.51 × 10–5) and short sleep (≤ 6 h; OR, 0.98; 95%CI, 0.97–0.99; P = 1.51 × 10–5), while higher SA in posterior cingulate cortex resulted in a vulnerability to shorter sleep durations (β, − 0.09; 95%CI, − 0.13 to − 0.05; P = 1.21 × 10–5).ConclusionsSleep habits not only result from but also contribute to alterations in brain structure, which may shed light on the possible mechanisms linking sleep behaviours with neuropsychiatric disorders, and offer new strategies for prevention and intervention in psychiatric disorders and sleep disturbance.

【 授权许可】

CC BY   
© BioMed Central Ltd. 2023

【 图 表 】

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