Molecular aspects of development and regulation of endometriosis

Reproductive Biology and Endocrinology

Review

Tiffany K Roberts¹  Yana B Aznaurova²  Marat B Zhumataev²  Alex A Zhavoronkov³  Alexander M Aliper⁴ 

[1] Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA;I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation;The First Open Institute for Regenerative Medicine for Young Scientists, Moscow, Russian Federation;Federal Research and Clinical Center for Pediatric Hematology, Oncology and Hematology,, Moscow, Russian Federation;I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation;The First Open Institute for Regenerative Medicine for Young Scientists, Moscow, Russian Federation;The Biogerontology Research Foundation,, London, UK;The First Open Institute for Regenerative Medicine for Young Scientists, Moscow, Russian Federation;Federal Research and Clinical Center for Pediatric Hematology, Oncology and Hematology,, Moscow, Russian Federation;Moscow Institute of Physics and Technology, Moscow, Russian Federation;

关键词: Endometriosis;    Reproductive age;    Bioinformatics analysis;    Signaling pathways;    Biomarkers;    Therapeutic targets;   

DOI  :  10.1186/1477-7827-12-50

 received in 2014-03-16, accepted in 2014-05-29,  发布年份 2014

来源: Springer

【 摘 要 】

Endometriosis is a common and painful condition affecting women of reproductive age. While the underlying pathophysiology is still largely unknown, much advancement has been made in understanding the progression of the disease. In recent years, a great deal of research has focused on non-invasive diagnostic tools, such as biomarkers, as well as identification of potential therapeutic targets. In this article, we will review the etiology and cellular mechanisms associated with endometriosis as well as the current diagnostic tools and therapies. We will then discuss the more recent genomic and proteomic studies and how these data may guide development of novel diagnostics and therapeutics. The current diagnostic tools are invasive and current therapies primarily treat the symptoms of endometriosis. Optimally, the advancement of “-omic” data will facilitate the development of non-invasive diagnostic biomarkers as well as therapeutics that target the pathophysiology of the disease and halt, or even reverse, progression. However, the amount of data generated by these types of studies is vast and bioinformatics analysis, such as we present here, will be critical to identification of appropriate targets for further study.

【 授权许可】

CC BY   
© Aznaurova et al.; licensee BioMed Central Ltd. 2014