Mammalian target of rapamycin signaling in diabetic cardiovascular disease

Cardiovascular Diabetology

Review

Kenneth Maiese¹  Zhao Zhong Chong² 

[1] Laboratory of Cellular and Molecular Signaling, Newark, NJ, USA;Cancer Institute of New Jersey, New Jersey Health Sciences University, 205 South Orange Avenue, 07101, Newark, NJ, USA;New Jersey Health Sciences University, 07101, Newark, NJ, USA;Laboratory of Cellular and Molecular Signaling, Newark, NJ, USA;New Jersey Health Sciences University, 07101, Newark, NJ, USA;

关键词: Akt;    AMPK;    Cardiac;    Diabetes Mellitus;    Endothelial;    Insulin Receptor Substrate 1;    Sirtuin;    SIRT1;    TORC1;    TORC2;   

DOI  :  10.1186/1475-2840-11-45

 received in 2012-04-04, accepted in 2012-04-30,  发布年份 2012

来源: Springer

【 摘 要 】

Diabetes mellitus currently affects more than 170 million individuals worldwide and is expected to afflict another 200 million individuals in the next 30 years. Complications of diabetes as a result of oxidant stress affect multiple systems throughout the body, but involvement of the cardiovascular system may be one of the most severe in light of the impact upon cardiac and vascular function that can result in rapid morbidity and mortality for individuals. Given these concerns, the signaling pathways of the mammalian target of rapamycin (mTOR) offer exciting prospects for the development of novel therapies for the cardiovascular complications of diabetes. In the cardiovascular and metabolic systems, mTOR and its multi-protein complexes of TORC1 and TORC2 regulate insulin release and signaling, endothelial cell survival and growth, cardiomyocyte proliferation, resistance to β-cell injury, and cell longevity. Yet, mTOR can, at times, alter insulin signaling and lead to insulin resistance in the cardiovascular system during diabetes mellitus. It is therefore vital to understand the complex relationship mTOR and its downstream pathways hold during metabolic disease in order to develop novel strategies for the complications of diabetes mellitus in the cardiovascular system.

【 授权许可】

CC BY   
© Chong and Maiese; licensee BioMed Central Ltd. 2012