Effect of provision of non-alcoholic beverages on alcohol consumption: a randomized controlled study

BMC Medicine

Research Article

Yukiko Owaki¹  Shohei Dobashi¹  Kyoko Kawaida¹  Hisashi Yoshimoto²  Go Saito³ 

[1] Research and Development Center for Lifestyle Innovation, University of Tsukuba, 1-2 Kasuga, 305-8550, Tsukuba, Ibaraki, Japan;Research and Development Center for Lifestyle Innovation, University of Tsukuba, 1-2 Kasuga, 305-8550, Tsukuba, Ibaraki, Japan;Department of Family Medicine, General Practice and Community Health, Institute of Medicine, University of Tsukuba, Tsukuba, Japan;Research and Development Center for Lifestyle Innovation, University of Tsukuba, 1-2 Kasuga, 305-8550, Tsukuba, Ibaraki, Japan;Department of Primary Care and Medical Education, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan;

关键词: Non-alcoholic beverages;    Reduced alcohol consumption;    Randomized controlled study;   

DOI  :  10.1186/s12916-023-03085-1

 received in 2023-05-26, accepted in 2023-09-20,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe use of alcohol-flavored beverages not containing alcohol (hereinafter referred to as non-alcoholic beverages) is recommended to reduce alcohol consumption. However, it is unclear if this reduces excessive drinking.ObjectiveTo verify whether non-alcoholic beverages impact the alcohol consumption of excessive drinkers.Study designSingle-center, open-label, randomized, parallel-group study.MethodsParticipants aged 20 years or older who were not diagnosed with alcoholism, who drank at least four times a week, and whose alcohol consumption on those days was at least 40 g in males and 20 g in females, were recruited. Participants were randomized into the intervention or control group by simple randomization using a random number table. In the intervention group, free non-alcoholic beverages were provided once every 4 weeks for 12 weeks (three times in total), and thereafter, the number of alcoholic and non-alcoholic beverages consumed were recorded for up to 20 weeks. The consumption of alcoholic and non-alcoholic beverages was calculated based on a drinking diary submitted with the previous 4 weeks of data. The primary endpoint was the change from baseline in total alcohol consumption during past 4 weeks at week 12. The participants were not blinded to group allocations.ResultsFifty-four participants (43.9%) were allocated to the intervention group and 69 (56.1%) to the control group. None of the participants in the intervention group dropped out, compared to two (1.6%) in the control group. The change in alcohol consumption was − 320.8 g (standard deviation [SD], 283.6) in the intervention group and − 76.9 g (SD, 272.6) in the control group at Week 12, indicating a significant difference (p < 0.001). Even at Week 20 (8 weeks after the completion of the intervention), the change was − 276.9 g (SD, 39.1) in the intervention group, which was significantly greater than − 126.1 g (SD, 41.3) in the control group (p < 0.001). The Spearman rank correlation coefficient between the change in non-alcoholic beverage consumption and alcohol consumption at Week 12 was significantly negative only in the intervention group (ρ =  − 0.500, p < 0.001). There were no reports of adverse events during the study.ConclusionsProviding non-alcoholic beverages significantly reduced alcohol consumption, an effect that persisted for 8 weeks after the intervention.Trial registrationUMIN UMIN000047949. Registered 4 June 2022.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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