Effect of a high bicarbonate mineral water on fasting and postprandial lipemia in moderately hypercholesterolemic subjects: a pilot study

Lipids in Health and Disease

Research

Mathieu Pichelin¹  Murielle Cazaubiel¹  Beatrice Housez¹  Yassine Zair²  Khadija Ouguerram³  Fatima Kasbi-Chadli³  François Raoux⁴ 

[1] BIOFORTIS, 3 route de la Chatterie, 44800, Saint-Herblain, France;L'Institut du thorax, IRT, BP 70721, 8 quai Moncousu, Cedex 1 44007, Nantes, France;L'Institut du thorax, IRT, BP 70721, 8 quai Moncousu, Cedex 1 44007, Nantes, France;CRNH, Human Nutrition Research Center of Nantes, CHU, F-44093, Nantes, France;Multimed, villa Lantiez, 75017, Paris, France;

关键词: Postprandial State;    Carbonate Water;    Postprandial Lipemia;    Bile Acid Excretion;    Hypercholesterolemic Subject;   

DOI  :  10.1186/1476-511X-12-105

 received in 2013-02-11, accepted in 2013-06-23,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundDuring postprandial state, TG concentration is increasing and HDL cholesterol decreasing, leading to a transitory pro-atherosclerotic profile. Previous studies have reported that bicarbonate water improve postprandial lipemia. The objective of this study was to analyze the effect of a strongly bicarbonated mineral water on lipoprotein levels during fasting and postprandial state.MethodsA controlled, randomised, double-blind cross-over design was conducted in 12 moderately hypercholesterolemic subjects after a daily ingestion of 1.25 L of mineral (SY) or low mineral water during eight weeks separated by a one week wash-out period. Blood samples were collected in first visit to the hospital (V1) before water consumption (referent or SY) and in a second visit (V2) after eight week water consumption period. The effect of the consumed water was studied in fasting and in postprandial state during ingestion of a meal and 0.5 L of water.ResultsComparison of data between V1 and V2 after SY consumption showed a significant decrease in triglyceridemia (23%), VLDL TG (31%) and tendency to a decrease of VLDL cholesterol (p = 0.066) at fasting state. Whatever the consumed water during postprandial state, the measurement of total areas under curves did not show a significant difference. No difference was observed between SY and referent water consumption for measured parameters at fasting and postprandial state.ConclusionWhen subjects consumed SY we showed a decrease of their basal TG and VLDLTG. The unexpected absence of effect of high mineralized water on postprandial lipemia, probably related to experimental conditions, is discussed in the discussion section.

【 授权许可】

Unknown   
© Zair et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.