Blood lipids and adipokines concentrations during a 6-month nutritional and physical activity intervention for metabolic syndrome treatment

Lipids in Health and Disease

Research

Eric Doré¹  Daniel Courteix¹  Gérard Lac¹  Bruno Lesourd²  Frédéric Dutheil³  Robert Chapier⁴ 

[1] Clermont University Blaise Pascal, BP 10448, BAPS, EA 3533, F 63000, Clermont-Ferrand, France;Clermont University Blaise Pascal, BP 10448, BAPS, EA 3533, F 63000, Clermont-Ferrand, France;Geriatrics department, Faculty of medicine, F 63000, Clermont-Ferrand, France;Clermont University Blaise Pascal, BP 10448, BAPS, EA 3533, F 63000, Clermont-Ferrand, France;Geriatrics department, Faculty of medicine, F 63000, Clermont-Ferrand, France;Occupational medicine, Faculty of medicine, F 63000, Clermont-Ferrand, France;General practitioner, thermal baths, F 63140, Châtel-Guyon, France;

关键词: Metabolic Syndrome;    Waist Circumference;    Basal Metabolic Rate;    Rimonabant;    International Diabetes Federation;   

DOI  :  10.1186/1476-511X-9-148

 received in 2010-11-09, accepted in 2010-12-31,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundTo report changes in body weight, total and central fat mass, metabolic, hormonal and inflammatory parameters in overweight people who participated in a six months weight loss intervention associating diet management and exercise.Subjects and MethodsFourteen subjects (10 M, 4 F, mean age 62.9 ± 6.9 years, BMI 30.4+/- 3.8 kg/m2) presenting the characteristics of the Metabolic Syndrome (MS) were included in the survey. They followed a three weeks (D0 to D20) cure in a medical establishment and a six months (D20 to M3 and M6) follow up at home. During the cure, they receive a balanced diet corresponding to 500 Kcal deficit vs their dayly energy expenditure (DEE) and they exercised 2 to 3 hours per day.At D0, D20, M3 and M6, body composition (lean mass, total and central fat mass) was analyzed with DEXA, blood pressure was taken and blood was collected to evaluate glycaemia, triglycerides, total, LDL and HDL cholesterol, insulin, leptin and adiponectin levels, CRP and pro-inflammatory interleukines IL1, IL.6 and TNFalpha.ResultsAll parameters listed above except the cytokine were improved at D20, so that 4 subjects among 14 still presented the MS. After returning to home, these parameters remained stable.ConclusionThe efficacy of therapeutic lifestyle modifications with education and exercise and diet was demonstrated, but the compliance to the new healthy lifestyle initiated during the cure was not optimal.

【 授权许可】

Unknown   
© Dutheil et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.