Neck circumference and future cardiovascular events in a high-risk population—A prospective cohort study

Lipids in Health and Disease

Research

Yingnan Dai¹  Enze Jin¹  Xin Li¹  Xueqi Li¹  Xiaojing Wan¹ 

[1] The Fourth Affiliated Hospital of Harbin Medical University, 37 Yiyuan Street, 150001, Habin, China;

关键词: Waist Circumference;    Visceral Adipose Tissue;    Neck Circumference;    Cardiometabolic Risk Factor;    Fourth Affiliate Hospital;   

DOI  :  10.1186/s12944-016-0218-3

 received in 2015-09-21, accepted in 2016-03-02,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe distribution of adipose tissue has been evaluated in relation to cardiovascular risk factors and biochemical components of the metabolic syndrome. Neck circumference (NC) has been shown to have a strong relationship with cardiovascular disease (CVD) and may be a novel indicator of CVD. The aim of this study was to compare the incidence of CVD events in cohorts with different NC distributions, and to correlate NC with future CVD events and relative mortality.MethodsA prospective cohort study was performed on 12,151 high-risk cardiology outpatients from 2004 until 2014. Anthropometric parameters like body mass index, NC, waist circumference, and hip circumference were measured at baseline and follow-up and compared in different cohorts with high, medium, and low NC. Fatal and non-fatal CVD events were compared in the follow-up study, and survival analysis was conducted. Independent Chi-square tests were performed to compare the incidence of CVD events and mortality among the cohorts and analyze the interactions.ResultsThe subjects comprised of 6696 women and 5819 men who completed a mean 8.8-year follow-up. All of the participants had two or more CVD risk factors at baseline. At the end of the study, 4049 CVD events had occurred in 2304 participants. The incidence of non-fatal CVD events was 14.08, 16,65, and 25.21 % in the low-NC, medium-NC, and high-NC cohorts, respectively (p < 0.001). The all-cause mortality was 9.77, 11.93, and 19.31 %, and CVD mortality, 4.00, 6.29, and 8.01 %, respectively (p < 0.001). Compared with baseline, the number of CVD risk factors in participants had increased from 2.6, 3.0, and 3.4 to 3.5, 4.1, and 4.7 in the low-, medium-, and high-NC cohorts (34, 36, and 38 %), respectively. The event-free survival rate was 95.32, 80.15, and 75.47 %, respectively.ConclusionsA higher NC indicated a higher incidence of future fatal and non-fatal CVD events and all-cause mortality in both male and female high-risk participants. CVD risk factors increased more in the higher NC group. NC as a novel indicator of CVD showed good predictive ability for CVD events and mortality in a high-risk population.

【 授权许可】

CC BY   
© Dai et al. 2016