Treatment of one case of cerebral palsy combined with posterior visual pathway injury using autologous bone marrow mesenchymal stem cells

Journal of Translational Medicine

Research

Min Li¹  Hongbin Cheng¹  GuangHui Dai¹  Aixue Yu¹  Xiaodong Wang¹  Fangfang Zhang¹  Yihua An² 

[1] Department of stem cell transplantation, General Hospital of Chinese People’s Armed Police Forces, 100039, Beijing, China;Department of stem cell transplantation, General Hospital of Chinese People’s Armed Police Forces, 100039, Beijing, China;Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, 100050, Beijing, China;

关键词: Cerebral Palsy;    Visual Evoke Potential;    P100 Latency;    Bone Marrow Mesenchymal Stem Cell;    Nerve Repair;   

DOI  :  10.1186/1479-5876-10-100

 received in 2011-11-19, accepted in 2012-03-28,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundCerebral palsy is currently one of the major diseases that cause severe paralysis of the nervous system in children; approximately 9–30% of cerebral palsy patients are also visually impaired, for which no effective treatment is available. Bone marrow mesenchymal stem cells (BMSCs) have very strong self-renewal, proliferation, and pluripotent differentiation potentials. Therefore, autologous BMSC transplantation has become a novel method for treating cerebral palsy.MethodsAn 11-year-old boy had a clear history of dystocia and asphyxia after birth; at the age of 6 months, the family members observed that his gaze roamed and noted that he displayed a lack of attention. A brain MRI examination at the age of 7 years showed that the child had cerebral palsy with visual impairment (i.e., posterior visual pathway injury). The patient was hospitalized for 20 days and was given four infusions of intravenous autologous BMSCs. Before transplantation and 1, 6, and 12 months after transplantation, a visual evoked potential test, an electrocardiogram, routine blood tests, and liver and kidney function tests were performed.ResultsThe patient did not have any adverse reactions during hospitalization or postoperative follow-up. After discharge, the patient could walk more smoothly than he could before transplantation; furthermore, his vision significantly improved 6 months after transplantation, which was also supported by the electrophysiological examinations.ConclusionsThe clinical application of BMSCs is effective for improving vision in a patient with cerebral palsy combined with visual impairment.

【 授权许可】

Unknown   
© Li et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.